Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4639416 | 0.90 | GRM2 (0.39) | GRM2ALDH1A1GAAPOLBTSHR | |
| SCHEMBL4637798 | 0.88 | ALDH1A1 (0.39) | GRM2ALDH1A1GAAPOLBTSHR | |
| SCHEMBL4637803 | 0.86 | CDC7 (0.37) | GRM2ALDH1A1GAAPOLBTSHR | |
| SCHEMBL4638500 | 0.85 | POLB (0.41) | GRM2ALDH1A1GAAPOLBTSHR | |
| SCHEMBL4638930 | 0.84 | ALDH1A1 (0.38) | GRM2ALDH1A1GAAPOLBTSHR | |
| SCHEMBL4637824 | 0.80 | ALDH1A1 (0.44) | GRM2ALDH1A1GAAPOLBTSHR | |
| SCHEMBL4638086 | 0.78 | TACR1 (0.39) | GRM2ALDH1A1GAAPOLBTSHR | |
| SCHEMBL4637992 | 0.77 | GRM2 (0.37) | GRM2POLBPTGER4GRM5AKR1C3 | |
| SCHEMBL4637719 | 0.74 | GRM2 (0.39) | GRM2ALDH1A1GAAPOLBTSHR | |
| SCHEMBL4637820 | 0.72 | GAA (0.40) | GRM2ALDH1A1GAAPOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |