Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4640568 | 0.90 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL4641099 | 0.89 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4639774 | 0.84 | MGAM (0.38) | — | |
| SCHEMBL4270719 | 0.83 | S1PR1 (0.44) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL4271297 | 0.82 | S1PR1 (0.43) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL4276045 | 0.82 | EPHX2 (0.49) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL4639813 | 0.81 | S1PR1 (0.43) | S1PR1S1PR3 | |
| SCHEMBL4639469 | 0.81 | LMNA (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL4639603 | 0.80 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL4277016 | 0.79 | S1PR1 (0.45) | PDE4APDE4BPDE4CPDE4DS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954684-A2 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | Otsuka Pharmaceutical Co., Ltd. (JP) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007058338-A2 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-05-24 | — | — | WO | disclosed |