Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.39 |
| ▸ | SYK | P43405 | 4/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4639397 | 0.89 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4640557 | 0.85 | PDE4A (0.44) | PDE4APDE4BFPR2LMNAMAPT | |
| SCHEMBL4639774 | 0.83 | MGAM (0.38) | MAPTMAPK1HSD17B10HPGD | |
| SCHEMBL4274938 | 0.83 | PDE4B (0.40) | PDE4APDE4BSYKFPR2PDE4C | |
| SCHEMBL4639813 | 0.82 | S1PR1 (0.43) | LMNAMAPTMAPK1HSD17B10HPGD | |
| SCHEMBL4278525 | 0.82 | PDE4B (0.39) | PDE4APDE4BSYKFPR2TSHR | |
| SCHEMBL4274963 | 0.81 | PDE4B (0.42) | PDE4APDE4BSYKFPR2PDE4C | |
| SCHEMBL4640423 | 0.81 | PDE4A (0.43) | PDE4APDE4BFPR2LMNAMAPT | |
| SCHEMBL4640568 | 0.80 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4286025 | 0.79 | PDE4B (0.40) | PDE4APDE4BFPR2PDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954684-A2 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | Otsuka Pharmaceutical Co., Ltd. (JP) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007058338-A2 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-05-24 | — | — | WO | disclosed |