SCHEMBL4639400 — predicted protein targets

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	NR1H4	Q96RI1	10/20	0.37

▸	KMT2A	Q03164	2/20	0.36

▸	KDM4E	B2RXH2	1/20	0.35

▸	ALDH1A1	P00352	3/20	0.34

▸	TSHR	P16473	1/20	0.34

▸	NPSR1	Q6W5P4	1/20	0.33

▸	VDR	P11473	2/20	0.33

▸	PPARD	Q03181	1/20	0.33

▸	L3MBTL1	Q9Y468	1/20	0.32

▸	LIFR	P42702	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4639398	0.84	KMT2A (0.37)	NR1H4KMT2AKDM4EALDH1A1TSHR
SCHEMBL4639395	0.81	EPAS1 (0.40)	NR1H4KMT2AKDM4EALDH1A1TSHR
SCHEMBL4638837	0.81	ALDH1A1 (0.38)	NR1H4KMT2AALDH1A1TSHRPPARD
SCHEMBL4637845	0.77	EPAS1 (0.41)	KMT2AKDM4EALDH1A1TSHRL3MBTL1
SCHEMBL4638634	0.76	ALDH1A1 (0.39)	KMT2AKDM4EALDH1A1TSHRL3MBTL1
SCHEMBL4638841	0.76	TACR1 (0.34)	KMT2AKDM4EALDH1A1TSHRL3MBTL1
SCHEMBL4707874	0.76	EPAS1 (0.39)	KMT2AKDM4EALDH1A1TSHRL3MBTL1
SCHEMBL4637694	0.76	EPAS1 (0.39)	KMT2AKDM4EALDH1A1TSHRL3MBTL1
SCHEMBL4637876	0.76	EPAS1 (0.39)	KMT2AKDM4EALDH1A1TSHRL3MBTL1
SCHEMBL4638045	0.75	EPAS1 (0.39)	KMT2AKDM4EALDH1A1TSHRL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1501808-B1	TACHYKININ RECEPTOR ANTAGONISTS	LILLY CO ELI (US)	2008-07-02	—	—	EP	disclosed