Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4639480 | 0.95 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DFPR2 | |
| SCHEMBL4639868 | 0.93 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DFPR2 | |
| SCHEMBL4640557 | 0.93 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DFPR2 | |
| SCHEMBL4639456 | 0.93 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DFPR2 | |
| SCHEMBL4639471 | 0.90 | PDE4B (0.40) | PDE4APDE4BPDE4CPDE4DFPR2 | |
| SCHEMBL4639383 | 0.85 | PDE4D (0.42) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4640577 | 0.84 | KDM4E (0.39) | MAPTLMNATHRBKDM4EMEN1 | |
| SCHEMBL4639690 | 0.83 | MAPT (0.43) | MAPTLMNAKDM4EMEN1USP2 | |
| SCHEMBL4639629 | 0.83 | PARP1 (0.44) | PDE4BMAPTLMNATHRBKDM4E | |
| SCHEMBL4639422 | 0.82 | SMN1; SMN2 (0.42) | FPR2MAPTLMNAKDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954684-A2 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | Otsuka Pharmaceutical Co., Ltd. (JP) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007058338-A9 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | OTSUKA PHARMA CO LTD (JP) | 2007-11-01 | — | — | WO | disclosed |
| WO-2007058338-A2 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-05-24 | — | — | WO | disclosed |