SCHEMBL4640672

SCHEMBL4640672

CC(C)(C)OC(=O)NCCCn1cnc2c(Cl)ncnc21

nearest known ligand 0.46

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
STK17B O94768 1/20 0.46
STK17A Q9UEE5 1/20 0.46
FGFR1 P11362 8/20 0.45
FGFR4 P22455 8/20 0.45
DOT1L Q8TEK3 1/20 0.45
HDAC6 Q9UBN7 1/20 0.44
P2RX7 Q99572 2/20 0.44
DRD2 P14416 2/20 0.43
FDPS P14324 1/20 0.43
ADCY5 O95622 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27410500 0.97 STK17B (0.45) STK17BSTK17AFGFR1FGFR4DOT1L
SCHEMBL4644008 0.96 DRD2 (0.45) STK17BSTK17AFGFR1FGFR4DOT1L
SCHEMBL4640082 0.93 FGFR1 (0.47) STK17BSTK17AFGFR1FGFR4DOT1L
SCHEMBL22359200 0.83 ADCY5 (0.57) FGFR1DOT1LADCY5
SCHEMBL26348187 0.83 STK17B (0.49) STK17BSTK17AHDAC6P2RX7DRD2
SCHEMBL21591519 0.82 FGFR1 (0.51) FGFR1FGFR4HDAC6P2RX7FDPS
SCHEMBL6805557 0.80 P2RX7 (0.48) FGFR1FGFR4HDAC6P2RX7FDPS
SCHEMBL17297735 0.80 PI4KA (0.55) FGFR1DOT1LADCY5
SCHEMBL17150783 0.79 P2RX7 (0.45) STK17BSTK17AHDAC6P2RX7DRD2
SCHEMBL12049642 0.78 FGFR1 (0.58) FGFR1FGFR4HDAC6P2RX7DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12162863-B2 Modulators of stimulator of interferon genes (STING) Ryvu Therapeutics S.A. (PL) 2024-12-10 US disclosed
US-20220402898-A1 MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) Ryvu Therapeutics S.A. (PL) 2022-12-22 US disclosed
US-20220402898-A1 MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) Ryvu Therapeutics S.A. (PL) 2022-12-22 US disclosed
WO-2019238786-A1 MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) Ryvu Therapeutics S.A. (PL) 2019-12-19 WO disclosed
EP-0853084-B1 Substituted purine derivatives as vitronectin receptor antagonists HOECHST AG (DE) 2008-08-13 EP disclosed
US-6723727-B1 VITRONECTIN RECEPTOR ANTAGONISTS; INHIBITORS OF BONE RESORPTION; OSTEOPOROSIS HOECHST AKTIENGESELLSCHAFT (DE) 2004-04-20 US disclosed
EP-0853084-A2 Substituted purine derivatives as vitronectin receptor antagonists HOECHST AKTIENGESELLSCHAFT (DE) 1998-07-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12162863-B2 Modulators of stimulator of interferon genes (STING) STING1, IRF3, CGAS STK17B 1120/4885STK17A 996/4885FGFR1 2759/4885
US-20220402898-A1 MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) STING1, IRF3, CGAS STK17B 1120/4885STK17A 996/4885FGFR1 2759/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.