Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.48 |
| ▸ | FDPS | P14324 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 8/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | POLA1 | P09884 | 1/20 | 0.39 |
| ▸ | POLG | P54098 | 1/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | ADCY5 | O95622 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9545171 | 0.87 | P2RX7 (0.56) | P2RX7FDPSFGFR1FGFR4HDAC6 | |
| SCHEMBL9534919 | 0.86 | P2RX7 (0.51) | P2RX7FDPSFGFR1FGFR4HDAC6 | |
| SCHEMBL4640082 | 0.82 | FGFR1 (0.47) | P2RX7FDPSFGFR1FGFR4HDAC6 | |
| SCHEMBL4640672 | 0.80 | STK17B (0.46) | P2RX7FDPSFGFR1FGFR4HDAC6 | |
| SCHEMBL9533818 | 0.80 | P2RX7 (0.56) | P2RX7FDPSFGFR1FGFR4HDAC6 | |
| SCHEMBL27410500 | 0.79 | STK17B (0.45) | P2RX7FDPSFGFR1FGFR4HDAC6 | |
| SCHEMBL4644008 | 0.78 | DRD2 (0.45) | P2RX7FDPSFGFR1FGFR4HDAC6 | |
| SCHEMBL4414495 | 0.77 | EP300 (0.50) | P2RX7FDPSFGFR1FGFR4HDAC6 | |
| SCHEMBL12049642 | 0.76 | FGFR1 (0.58) | P2RX7FGFR1FGFR4HDAC6ADORA2A | |
| SCHEMBL5106770 | 0.75 | P2RX7 (0.41) | P2RX7FDPSFGFR1FGFR4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723727-B1 | VITRONECTIN RECEPTOR ANTAGONISTS; INHIBITORS OF BONE RESORPTION; OSTEOPOROSIS | HOECHST AKTIENGESELLSCHAFT (DE) | 2004-04-20 | — | — | US | disclosed |