Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1561069 | 1.00 | EPHX2 (0.42) | EPHX2HSD11B1ALDH1A1NPSR1MEN1 | |
| SCHEMBL1605461 | 0.86 | HSD11B1 (0.42) | HSD11B1ALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL1560814 | 0.78 | EPHX2 (0.41) | EPHX2ALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL1605577 | 0.77 | HSD11B1 (0.39) | HSD11B1MEN1KMT2ATAAR1SMN1; SMN2 | |
| SCHEMBL10249402 | 0.76 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2AHKDC1PKM | |
| SCHEMBL1605500 | 0.74 | GAA (0.53) | HSD11B1ALDH1A1KMT2AMAPK1LMNA | |
| SCHEMBL1605156 | 0.74 | LMNA (0.44) | HSD11B1MEN1KMT2ATAAR1MAPK1 | |
| SCHEMBL1606574 | 0.74 | LMNA (0.44) | HSD11B1MEN1KMT2ATAAR1MAPK1 | |
| SCHEMBL1605158 | 0.74 | LMNA (0.44) | HSD11B1MEN1KMT2ATAAR1MAPK1 | |
| SCHEMBL10249047 | 0.73 | USP2 (0.44) | ALDH1A1NPSR1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951696-A2 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | Amgen Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007061661-A2 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | AMGEN INC. (US) | 2007-05-31 | — | — | WO | disclosed |