Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 19/20 | 0.68 |
| ▸ | ITGAV | P06756 | 19/20 | 0.68 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.53 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4641327 | 0.92 | ITGB3 (0.59) | ITGB3ITGAVITGA2BITGB5HDAC1 | |
| SCHEMBL6805087 | 0.84 | ITGB3 (0.57) | ITGB3ITGAVITGA2BITGB5HDAC1 | |
| SCHEMBL6806785 | 0.80 | ITGB3 (0.51) | ITGB3ITGAVITGA2BITGB5HDAC1 | |
| SCHEMBL4640796 | 0.77 | ITGB3 (0.47) | ITGB3ITGAVHDAC1HDAC2 | |
| SCHEMBL4640793 | 0.77 | ITGB3 (0.47) | ITGB3ITGAVHDAC1HDAC2 | |
| SCHEMBL6806782 | 0.76 | ITGB3 (0.46) | ITGB3ITGAVITGA2BITGB5HDAC1 | |
| SCHEMBL5840142 | 0.76 | HDAC6 (0.47) | ITGB3ITGAV | |
| SCHEMBL4641275 | 0.74 | ITGB3 (0.43) | ITGB3ITGAVHDAC1HDAC2 | |
| SCHEMBL4641283 | 0.74 | ITGB3 (0.46) | ITGB3ITGAVHDAC1HDAC2 | |
| SCHEMBL6804197 | 0.73 | ITGB3 (0.47) | ITGB3ITGAVHDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0853084-B1 | Substituted purine derivatives as vitronectin receptor antagonists | HOECHST AG (DE) | 2008-08-13 | — | — | EP | disclosed |
| US-6723727-B1 | VITRONECTIN RECEPTOR ANTAGONISTS; INHIBITORS OF BONE RESORPTION; OSTEOPOROSIS | HOECHST AKTIENGESELLSCHAFT (DE) | 2004-04-20 | — | — | US | disclosed |
| EP-0853084-A2 | Substituted purine derivatives as vitronectin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-15 | — | — | EP | disclosed |