SCHEMBL4641232

SCHEMBL4641232

Cc1ccc(NCCO)cc1O.OCCNc1cccc(O)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.46
RAPGEF4 Q8WZA2 1/20 0.44
CYP1A2 P05177 4/20 0.42
CYP3A4 P08684 3/20 0.42
CYP2D6 P10635 3/20 0.42
CYP2C9 P11712 3/20 0.42
CYP2C19 P33261 3/20 0.42
MAPT P10636 2/20 0.42
HTT P42858 1/20 0.42
TAAR1 Q96RJ0 1/20 0.41
TUBB4A P04350 1/20 0.41
TUBB P07437 1/20 0.41
TUBA3C P0DPH7 1/20 0.41
TUBA1B P68363 1/20 0.41
TUBA4A P68366 1/20 0.41
TUBB4B P68371 1/20 0.41
TUBB3 Q13509 1/20 0.41
TUBB2A Q13885 1/20 0.41
TUBB8 Q3ZCM7 1/20 0.41
TUBA3E Q6PEY2 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL95129 0.89 ALDH1A1 (0.56) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL29428385 0.89 ALDH1A1 (0.56) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL453961 0.85 CYP3A4 (0.50) ALDH1A1RAPGEF4CYP1A2CYP3A4CYP2D6
SCHEMBL29602312 0.85 CYP3A4 (0.50) ALDH1A1RAPGEF4CYP1A2CYP3A4CYP2D6
SCHEMBL28107583 0.85 ALDH1A1 (0.46) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL6557096 0.84 CASP1 (0.47) ALDH1A1RAPGEF4CYP1A2CYP3A4CYP2D6
Hydrochloric Acid SCHEMBL11216788 0.84 TAAR1 (0.52) ALDH1A1RAPGEF4CYP1A2CYP3A4CYP2D6
Sulfuric Acid SCHEMBL17976587 0.81 ALDH1A1 (0.53) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL6390338 0.80 ALDH1A1 (0.42) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL693140 0.80 CASP1 (0.59) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7033401-B2 3-Aminophenol derivatives substituted in the 2-position, and dyes containing these compounds WELLA AG (DE) 2006-04-25 US claimed
EP-1888023-A1 COLORANTS FOR KERATIN FIBERS Wella Aktiengesellschaft (DE) 2008-02-20 EP disclosed
US-20070006397-A1 Colorants for keratin fibers PROCTER & GAMBLE COMPANY, THE 2007-01-11 US disclosed
WO-2006130373-A1 COLORANTS FOR KERATIN FIBERS THE PROCTER & GAMBLE COMPANY (US) 2006-12-07 WO disclosed