Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 12/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4642274 | 0.99 | ADRB3 (0.41) | ADRB3ADRB2ADRB1ALDH1A1NPSR1 | |
| SCHEMBL4908096 | 0.89 | ADRB3 (0.42) | ADRB3ADRB2ADRB1ALDH1A1NPSR1 | |
| Hydrochloric Acid SCHEMBL4916184 | 0.88 | ADRB3 (0.41) | ADRB3ADRB2ADRB1ALDH1A1NPSR1 | |
| SCHEMBL4832542 | 0.88 | ADRB3 (0.40) | ADRB3ADRB2ADRB1ALDH1A1NPSR1 | |
| SCHEMBL4645453 | 0.87 | ADRB3 (0.45) | ADRB3ADRB2ADRB1ALDH1A1NPSR1 | |
| SCHEMBL4643457 | 0.87 | ADRB3 (0.47) | ADRB3ALDH1A1OPRM1OPRD1LMNA | |
| SCHEMBL4640303 | 0.87 | ADRB3 (0.47) | ADRB3ALDH1A1OPRM1OPRD1LMNA | |
| SCHEMBL4640763 | 0.87 | ADRB3 (0.45) | ADRB3ADRB2ADRB1ALDH1A1NPSR1 | |
| SCHEMBL4840747 | 0.86 | ADRB3 (0.42) | ADRB3ADRB2ADRB1ALDH1A1NPSR1 | |
| SCHEMBL4777081 | 0.86 | ADRB3 (0.42) | ADRB3ADRB2ADRB1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943229-A1 | BENZIMIDAZOLE DERIVATIVES FOR USE AS BETA-3 RECEPTOR AGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007048842-A1 | BENZIMIDAZOLE DERIVATIVES FOR USE AS BETA-3 RECEPTOR AGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-03 | — | — | WO | disclosed |