Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 8/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 7/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4640303 | 1.00 | ADRB3 (0.47) | ADRB3NR1I2HPGDOPRM1OPRD1 | |
| SCHEMBL4645453 | 0.94 | ADRB3 (0.45) | ADRB3NR1I2HPGDOPRM1OPRD1 | |
| SCHEMBL4640763 | 0.94 | ADRB3 (0.45) | ADRB3NR1I2HPGDOPRM1OPRD1 | |
| SCHEMBL1379766 | 0.92 | ADRB3 (0.48) | ADRB3NR1I2HPGDOPRM1OPRD1 | |
| SCHEMBL4777081 | 0.90 | ADRB3 (0.42) | ADRB3NR1I2HPGDOPRM1OPRD1 | |
| SCHEMBL4776666 | 0.90 | ADRB3 (0.42) | ADRB3NR1I2HPGDOPRM1OPRD1 | |
| SCHEMBL4737488 | 0.90 | ADRB3 (0.46) | ADRB3NR1I2HPGDOPRM1OPRD1 | |
| SCHEMBL4916377 | 0.89 | ADRB3 (0.43) | ADRB3NR1I2HPGDOPRM1OPRD1 | |
| SCHEMBL2199546 | 0.89 | ADRB3 (0.43) | ADRB3NR1I2HPGDOPRM1OPRD1 | |
| SCHEMBL4840747 | 0.88 | ADRB3 (0.42) | ADRB3NR1I2HPGDOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943229-A1 | BENZIMIDAZOLE DERIVATIVES FOR USE AS BETA-3 RECEPTOR AGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007048842-A1 | BENZIMIDAZOLE DERIVATIVES FOR USE AS BETA-3 RECEPTOR AGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-03 | — | — | WO | disclosed |