Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | TP53 | P04637 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1F | P30939 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4643537 | 0.89 | MAPT (0.42) | MAPTTP53THRBSMN1; SMN2KDM4E | |
| SCHEMBL5244396 | 0.88 | MAPT (0.51) | MAPTTP53MAPK1THRBSMN1; SMN2 | |
| SCHEMBL13054294 | 0.88 | MAPT (0.51) | MAPTTP53MAPK1THRBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5248239 | 0.88 | MAPT (0.50) | MAPTTP53MAPK1THRBSMN1; SMN2 | |
| SCHEMBL4643115 | 0.83 | PTGDR2 (0.43) | MAPTTP53MAPK1THRBSMN1; SMN2 | |
| SCHEMBL4641319 | 0.82 | MAPT (0.42) | MAPTTP53THRBSMN1; SMN2KDM4E | |
| SCHEMBL4641261 | 0.82 | KDM4E (0.44) | MAPTTP53THRBSMN1; SMN2KDM4E | |
| SCHEMBL4646624 | 0.81 | MAPT (0.42) | MAPTTP53THRBSMN1; SMN2KDM4E | |
| SCHEMBL4641580 | 0.80 | MAPT (0.48) | MAPTTP53THRBSMN1; SMN2KDM4E | |
| SCHEMBL5290458 | 0.77 | MAPT (0.52) | MAPTTP53THRBSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |