Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | TP53 | P04637 | 5/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4643630 | 0.89 | MAPT (0.41) | MAPTTP53SMN1; SMN2THRBKDM4E | |
| SCHEMBL5290458 | 0.88 | MAPT (0.52) | MAPTTP53SMN1; SMN2THRBKDM4E | |
| SCHEMBL4643045 | 0.87 | CHRM3 (0.40) | MAPTCHRM3SMN1; SMN2THRBKDM4E | |
| SCHEMBL4643115 | 0.86 | PTGDR2 (0.43) | MAPTTP53SMN1; SMN2THRBKDM4E | |
| SCHEMBL4646624 | 0.85 | MAPT (0.42) | MAPTTP53SMN1; SMN2THRBKDM4E | |
| SCHEMBL4641261 | 0.83 | KDM4E (0.44) | MAPTTP53SMN1; SMN2THRBKDM4E | |
| SCHEMBL4641319 | 0.82 | MAPT (0.42) | MAPTTP53SMN1; SMN2THRBKDM4E | |
| SCHEMBL3748607 | 0.82 | MCHR1 (0.49) | MAPTTP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4641580 | 0.82 | MAPT (0.48) | MAPTTP53SMN1; SMN2THRBKDM4E | |
| SCHEMBL4641189 | 0.81 | CHRM3 (0.41) | MAPTTP53CHRM3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |