Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 11/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4645627 | 0.93 | ALDH1A1 (0.41) | PTGDR2MAPTTP53KDM4ENPC1 | |
| SCHEMBL4646624 | 0.90 | MAPT (0.42) | PTGDR2MAPTTP53THRBKDM4E | |
| SCHEMBL13054177 | 0.88 | MAPT (0.52) | PTGDR2MAPTTP53THRBKDM4E | |
| SCHEMBL4643537 | 0.86 | MAPT (0.42) | PTGDR2MAPTTP53THRBKDM4E | |
| SCHEMBL4641368 | 0.83 | PTGDR2 (0.40) | PTGDR2MAPTTP53THRBPOLB | |
| SCHEMBL4643630 | 0.83 | MAPT (0.41) | PTGDR2MAPTTP53THRBKDM4E | |
| SCHEMBL4641300 | 0.83 | AGPAT2 (0.42) | MAPTTP53THRBKDM4ENPC1 | |
| SCHEMBL4643098 | 0.82 | MAPT (0.46) | PTGDR2MAPTTP53KDM4ENPC1 | |
| SCHEMBL4645865 | 0.81 | PTGDR2 (0.41) | PTGDR2MAPTTP53KCNH2MALT1 | |
| SCHEMBL13054173 | 0.81 | MCHR1 (0.46) | MAPTTP53THRBKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |