Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.68 |
| ▸ | HCAR3 | P49019 | 7/20 | 0.59 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PNP | P00491 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4646927 | 0.75 | KDM4C (0.52) | HCAR2HCAR3KDM4CNPC1HDAC8 | |
| SCHEMBL15286846 | 0.66 | KDM4C (1.00) | KDM4C | |
| Hydrochloric Acid SCHEMBL15286204 | 0.65 | KDM4C (0.97) | KDM4C | |
| SCHEMBL18415486 | 0.65 | GRM5 (0.53) | KDM4CNPC1HDAC8HDAC6GRM5 | |
| SCHEMBL6720904 | 0.64 | GRM5 (0.52) | KDM4CNPC1HDAC8HDAC6GRM5 | |
| SCHEMBL28518683 | 0.64 | HCAR3 (0.57) | HCAR2HCAR3NPC1CA12ALPL | |
| SCHEMBL28509025 | 0.64 | CXCR4 (0.66) | KDM4CNPC1TP53 | |
| SCHEMBL16763221 | 0.63 | HCAR3 (0.50) | HCAR2HCAR3CA12ALPLCA9 | |
| SCHEMBL9430237 | 0.62 | GRM5 (0.50) | KDM4CNPC1HDAC8HDAC6GRM5 | |
| SCHEMBL23942820 | 0.62 | NPC1 (0.58) | KDM4CNPC1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899304-A1 | 5-AMINO-1H-PYRAZOLE-3-CARBOXYLIC ACID DERIVATIVES AS AGONISTS FOR THE G-PROTEIN COUPLED RECEPTOR (GPCR) RUP38 FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006127595-A1 | 5-AMINOPYRAZOLE CARBOXYLIC ACID DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |