Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 2/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1044376 | 0.84 | HPGD (0.40) | MAPTLMNAL3MBTL1 | |
| SCHEMBL3103010 | 0.84 | HPGD (0.40) | MAPTLMNAL3MBTL1 | |
| SCHEMBL718202 | 0.84 | HPGD (0.40) | MAPTLMNAL3MBTL1 | |
| SCHEMBL3743645 | 0.84 | HPGD (0.40) | MAPTLMNAL3MBTL1 | |
| SCHEMBL3345242 | 0.80 | ALOX5 (0.47) | PRKCAPRKCDALOX5FFAR1MAOB | |
| SCHEMBL3345233 | 0.80 | ALOX5 (0.47) | PRKCAPRKCDALOX5FFAR1MAOB | |
| SCHEMBL4079035 | 0.78 | PPARG (0.50) | FFAR1MAOB | |
| SCHEMBL4344226 | 0.78 | PPARG (0.50) | FFAR1MAOB | |
| SCHEMBL970614 | 0.74 | CYP26A1 (0.37) | — | |
| SCHEMBL13117273 | 0.72 | LMNA (0.51) | ALOX5MAPTKMT2AMAOBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686113-B1 | Inhibitors of aspartyl protease | VERTEX PHARMA (US) | 2011-11-23 | — | — | EP | disclosed |