Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | SNCA | P37840 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.37 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL621196 | 0.86 | TDP1 (0.50) | ATMTDP1SNCAALDH1A1MAPT | |
| SCHEMBL310240 | 0.85 | ATM (0.53) | ATMTDP1SNCAALDH1A1MAPT | |
| SCHEMBL29362511 | 0.80 | TDP1 (0.60) | ATMTDP1SNCAALDH1A1MAPT | |
| SCHEMBL310839 | 0.80 | TDP1 (0.60) | ATMTDP1SNCAALDH1A1MAPT | |
| SCHEMBL405343 | 0.79 | ACHE (0.40) | ATMTDP1ALDH1A1MAPK1KMT2A | |
| SCHEMBL405093 | 0.79 | TSHR (0.55) | ATMALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL406455 | 0.79 | TSHR (0.56) | ALDH1A1MAPTKMT2ATSHR | |
| SCHEMBL12246128 | 0.79 | ALDH1A1 (0.44) | TDP1ALDH1A1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL463502 | 0.79 | TSHR (0.36) | ATMTDP1ALDH1A1MAPTMAPK1 | |
| SCHEMBL2891144 | 0.79 | TDP1 (0.58) | ATMTDP1SNCAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667989-A4 | SUBSTITUTED ISOQUINOLINONES | PORTOLA PHARM INC (US) | 2008-08-20 | — | — | EP | disclosed |
| EP-1667989-A1 | SUBSTITUTED ISOQUINOLINONES | Portola Pharmaceuticals, Inc. (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005035520-A1 | SUBSTITUTED ISOQUINOLINONES | PORTOLA PHARMACEUTICALS, INC. (US) | 2005-04-21 | — | — | WO | disclosed |