Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 4/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4647955 | 0.90 | TP53 (0.53) | HCAR3KMT2ATP53THRBPOLB | |
| SCHEMBL4648872 | 0.86 | HCAR3 (0.64) | HCAR3HCAR2KMT2AMMP13MMP1 | |
| SCHEMBL4648485 | 0.81 | HCAR2 (0.61) | HCAR3HCAR2KMT2ATRPM8 | |
| SCHEMBL4649196 | 0.76 | HCAR3 (0.53) | HCAR3HCAR2MMP13MMP1 | |
| SCHEMBL4648280 | 0.74 | HCAR3 (0.67) | HCAR3HCAR2KMT2APOLBTRPM8 | |
| SCHEMBL4621634 | 0.74 | HCAR2 (0.56) | HCAR3HCAR2MMP13MMP1 | |
| SCHEMBL4647495 | 0.73 | HCAR3 (0.49) | HCAR3HCAR2KMT2ATP53POLB | |
| SCHEMBL4648191 | 0.72 | HCAR3 (0.51) | HCAR3HCAR2KMT2APOLBTRPM8 | |
| SCHEMBL4647555 | 0.70 | POLB (0.43) | KMT2ATP53THRBPOLBNPSR1 | |
| SCHEMBL12827154 | 0.70 | THRB (0.52) | KMT2ATP53THRBPOLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899304-A1 | 5-AMINO-1H-PYRAZOLE-3-CARBOXYLIC ACID DERIVATIVES AS AGONISTS FOR THE G-PROTEIN COUPLED RECEPTOR (GPCR) RUP38 FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006127595-A1 | 5-AMINOPYRAZOLE CARBOXYLIC ACID DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |