Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALB | P02768 | 2/20 | 0.56 |
| ▸ | BLM | P54132 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | TK1 | P04183 | 2/20 | 0.47 |
| ▸ | TYMP | P19971 | 5/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL417308 | 0.78 | LMNA (0.60) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL1417635 | 0.77 | LMNA (0.62) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL11959609 | 0.77 | LMNA (0.65) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL933552 | 0.76 | LMNA (0.54) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL27841824 | 0.76 | LMNA (0.56) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL27809547 | 0.75 | LMNA (0.55) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL14232397 | 0.75 | LMNA (0.55) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL30976665 | 0.75 | LMNA (0.59) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL2158702 | 0.75 | LMNA (0.55) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL30505858 | 0.74 | LMNA (0.61) | LMNAALBBLMALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720856-B1 | HIV INTEGRASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-08-14 | — | — | EP | claimed |
| EP-1686113-B1 | Inhibitors of aspartyl protease | VERTEX PHARMA (US) | 2011-11-23 | — | — | EP | claimed |
| EP-1569931-B1 | HETEROCYCLIC COMPOUNDS AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-10-08 | — | — | EP | claimed |
| EP-1569647-B1 | CYCLOHEXYL COMPOUNDS AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-08-20 | — | — | EP | claimed |
| EP-1569933-B1 | PYRROLIDINE AND AZETIDINE COMPOUNDS AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-07-23 | — | — | EP | claimed |
| EP-1569934-B1 | CYCLOPROPYL COMPOUNDS AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-01-23 | — | — | EP | claimed |
| EP-1194404-B1 | INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMA (US) | 2006-05-03 | — | — | EP | claimed |
| EP-1027061-B1 | IMINE-FORMING POLYSACCHARIDES, PREPARATION THEREOF AND THE USE THEREOF AS ADJUVANTS AND IMMUNOSTIMULANTS | GALENICA PHARMACEUTICALS INC (US) | 2005-05-25 | — | — | EP | claimed |