Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | ALB | P02768 | 2/20 | 0.55 |
| ▸ | BLM | P54132 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | TK1 | P04183 | 7/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14232397 | 1.00 | LMNA (0.55) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL933552 | 0.88 | LMNA (0.54) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL25966495 | 0.88 | TK1 (0.52) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL12595723 | 0.87 | TK1 (0.56) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL2159268 | 0.85 | TK1 (0.52) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL18837842 | 0.81 | TK1 (0.66) | LMNAALBBLMTK1TSHR | |
| SCHEMBL925743 | 0.78 | LMNA (0.58) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL13286394 | 0.78 | LMNA (0.58) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL762579 | 0.78 | LMNA (0.58) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL22992337 | 0.78 | LMNA (0.58) | LMNAALBBLMALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110182973-A1 | POLYMERASE INHIBITORS AND THE USE THEREOF FOR THE TREATMENT OF TUMORS | FREIE UNIVERSITAET BERLIN (DE) | 2011-07-28 | — | — | US | claimed |
| WO-2008138327-A9 | POLYMERASE INHIBITORS AND THE USE THEREOF FOR THE TREATMENT OF TUMORS | FREIE UNIVERSITÄT BERLIN (DE) | 2009-12-30 | — | — | WO | claimed |
| WO-2008138327-A2 | POLYMERASE INHIBITORS AND THE USE THEREOF FOR THE TREATMENT OF TUMORS | FREIE UNIVERSITÄT BERLIN (DE) | 2008-11-20 | — | — | WO | claimed |
| EP-1990054-A1 | Polymerase inhibitors and their use in treating tumours | Freie Universität Berlin (DE) | 2008-11-12 | — | — | EP | claimed |
| US-20110182973-A1 | POLYMERASE INHIBITORS AND THE USE THEREOF FOR THE TREATMENT OF TUMORS | FREIE UNIVERSITAET BERLIN (DE) | 2011-07-28 | — | — | US | disclosed |
| WO-2008138327-A9 | POLYMERASE INHIBITORS AND THE USE THEREOF FOR THE TREATMENT OF TUMORS | FREIE UNIVERSITÄT BERLIN (DE) | 2009-12-30 | — | — | WO | disclosed |
| WO-2008138327-A2 | POLYMERASE INHIBITORS AND THE USE THEREOF FOR THE TREATMENT OF TUMORS | FREIE UNIVERSITÄT BERLIN (DE) | 2008-11-20 | — | — | WO | disclosed |
| EP-1990054-A1 | Polymerase inhibitors and their use in treating tumours | Freie Universität Berlin (DE) | 2008-11-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110182973-A1 | POLYMERASE INHIBITORS AND THE USE THEREOF FOR THE TREATMENT OF TUMORS | POLH, POLI, POLK | LMNA 634/4885ALB 4798/4885BLM 636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.