SCHEMBL4648170

SCHEMBL4648170

O=C(O)CCCC=CC[C@@H]1CC2CC(C2)[C@H]1NC(=O)c1csc2ccc(O)cc12

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGDR Q13258 20/20 0.74
TBXA2R P21731 5/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6866940 1.00 PTGDR (0.74) PTGDRTBXA2R
SCHEMBL6866936 1.00 PTGDR (0.74) PTGDRTBXA2R
SCHEMBL7115968 0.86 PTGDR (0.67) PTGDRTBXA2R
SCHEMBL7115977 0.86 PTGDR (0.67) PTGDRTBXA2R
SCHEMBL7115973 0.86 PTGDR (0.67) PTGDRTBXA2R
SCHEMBL7114327 0.86 PTGDR (0.67) PTGDRTBXA2R
SCHEMBL633588 0.85 PTGDR (1.00) PTGDRTBXA2R
SCHEMBL6150895 0.85 PTGDR (1.00) PTGDRTBXA2R
SCHEMBL6935578 0.85 PTGDR (1.00) PTGDRTBXA2R
SCHEMBL6936201 0.85 PTGDR (1.00) PTGDRTBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2912458-B1 NON-INVASIVE BIOMARKER TO IDENTIFY SUBJECTS AT RISK OF PRETERM DELIVERY NYU WINTHROP HOSPITAL (US) 2018-07-18 EP claimed
US-9797903-B2 Non-invasive biomarker to identify subject at risk of preterm delivery WINTHROP-UNIVERSITY HOSPITAL (US) 2017-10-24 US claimed
US-20150285800-A1 NON-INVASIVE BIOMARKER TO IDENTIFY SUBJECT AT RISK OF PRETERM DELIVERY NYU WINTHROP HOSPITAL 2015-10-08 US claimed
US-10408838-B2 Non-invasive biomarker to identify subject at risk of preterm delivery NYU WINTHROP HOSPITAL (US) 2019-09-10 US disclosed
EP-3382391-A1 NON-INVASIVE BIOMARKER TO IDENTIFY SUBJECTS AT RISK OF PRETERM DELIVERY NYU Winthrop Hospital (US) 2018-10-03 EP disclosed
EP-2912458-B1 NON-INVASIVE BIOMARKER TO IDENTIFY SUBJECTS AT RISK OF PRETERM DELIVERY NYU WINTHROP HOSPITAL (US) 2018-07-18 EP disclosed
US-20180003713-A1 NON-INVASIVE BIOMARKER TO IDENTIFY SUBJECT AT RISK OF PRETERM DELIVERY WINTHROP-UNIVERSITY HOSPITAL 2018-01-04 US disclosed
US-9797903-B2 Non-invasive biomarker to identify subject at risk of preterm delivery WINTHROP-UNIVERSITY HOSPITAL (US) 2017-10-24 US disclosed
US-20150285800-A1 NON-INVASIVE BIOMARKER TO IDENTIFY SUBJECT AT RISK OF PRETERM DELIVERY NYU WINTHROP HOSPITAL 2015-10-08 US disclosed
EP-1193243-B1 NOVEL PROCESS FOR PRODUCING BICYCLIC AMINO ALCOHOL SHIONOGI & CO (JP) 2008-08-13 EP disclosed
EP-1808427-A2 Novel processes for the preparation of bicyclic aminoalcohols SHIONOGI & CO., LTD. (JP) 2007-07-18 EP disclosed
US-20020115871-A1 Process for preparing benzothiophenecarboxamide derivatives OKADA TETSUO (JP) 2002-08-22 US disclosed
US-6399788-B1 AMIDATION SHIONOGI & CO., LTD. (JP) 2002-06-04 US disclosed
EP-1193243-A1 NOVEL PROCESS FOR PRODUCING BICYCLIC AMINO ALCOHOL SHIONOGI & CO., LTD. (JP) 2002-04-03 EP disclosed
US-20020026061-A1 Process for preparing 5-hydroxybenzo [b] thiophene-3-carboxylic acid derivatives HONMA TSUNETOSHI (JP) 2002-02-28 US disclosed
US-6346628-B1 REACTING 4-MERCAPTOPHENOL WITH A PROPARYGL GOUP AND PROTECTION OF HYDROXYL GROUP, OXIDIZING THE PRODUCT, AND THERMAL REARRANGEMENT TO CYCLIZE, FOLLOWED BY FURTHER OXIDATION SHIONOGI & CO., LTD. (JP) 2002-02-12 US disclosed
US-20020016476-A1 PROCESS FOR PREPARING 5-HYDROXYBENZO [B] THIOPHENE-3-CARBOXYLIC ACID DERIVATIVES HONMA TSUNETOSHI (JP) 2002-02-07 US disclosed
US-6320060-B1 INTRODUCING PROPARGYL GROUP INTO 4-MERCAPTOPHENOL, PROTECTING HYDROXYL GROUP, OXIDIZING COMPOUND, SUBJECTING TO THERMAL REARRANGEMENT REACTION, SUBJECTING TO STEPWISE OXIDATION OF HYDROXYMETHYL GROUP AND OPTIONALLY DEPROTECTION SHIONOGI & CO., LTD. (JP) 2001-11-20 US disclosed
EP-1069123-A1 PROCESS FOR PRODUCING BENZOTHIOPHENECARBOXYLIC ACID AMIDE DERIVATIVES SHIONOGI & CO., LTD. (JP) 2001-01-17 EP disclosed
EP-1069122-A1 PROCESS FOR PRODUCING 5-HYDROXYBENZO b]THIOPHENE-3-CARBOXYLIC ACID DERIVATIVES SHIONOGI & CO., LTD. (JP) 2001-01-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020016476-A1 PROCESS FOR PREPARING 5-HYDROXYBENZO [B] THIOPHENE-3-CARBOXYLIC ACID DERIVATIVES HPD, PTGDR2, PTGS2 PTGDR 4/4885TBXA2R 27/4885
US-20020115871-A1 Process for preparing benzothiophenecarboxamide derivatives PGD, HPD, PTGS2 PTGDR 11/4885TBXA2R 34/4885
US-20020026061-A1 Process for preparing 5-hydroxybenzo [b] thiophene-3-carboxylic acid derivatives HPD, PTGDR2, PTGS2 PTGDR 4/4885TBXA2R 27/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.