Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 3/20 | 0.40 |
| ▸ | CCR3 | P51677 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.39 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | PRKX | P51817 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378015 | 0.81 | HRH3 (0.45) | HRH1CCR3KCNH2ALDH1A1POLB | |
| SCHEMBL4646695 | 0.78 | HRH3 (0.40) | HRH1CCR3KCNH2KMT2AMEN1 | |
| SCHEMBL4647478 | 0.76 | LSS (0.47) | TSHRKMT2ALSSMEN1ALDH1A1 | |
| SCHEMBL4644327 | 0.76 | CCR3 (0.47) | CCR3 | |
| SCHEMBL3380045 | 0.75 | HRH3 (0.44) | HRH1CCR3KCNH2ALDH1A1POLB | |
| SCHEMBL3379505 | 0.75 | HRH3 (0.43) | HRH1CCR3KCNH2ALDH1A1POLB | |
| SCHEMBL3378463 | 0.75 | HRH3 (0.43) | HRH1CCR3KCNH2ALDH1A1POLB | |
| SCHEMBL3416630 | 0.75 | SOS1 (0.35) | HRH1CCR3KCNH2KMT2AMEN1 | |
| SCHEMBL3376588 | 0.75 | HRH3 (0.44) | HRH1CCR3KCNH2ALDH1A1POLB | |
| SCHEMBL3377859 | 0.74 | HRH3 (0.44) | HTR7HRH1CCR3ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2008-03-19 | — | — | EP | claimed |
| WO-2006136924-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-12-28 | — | — | WO | claimed |