Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | CCR3 | P51677 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378463 | 0.85 | HRH3 (0.43) | HRH3HRH1CCR3KCNH2OPRM1 | |
| SCHEMBL3379505 | 0.85 | HRH3 (0.43) | HRH3HRH1CCR3KCNH2OPRM1 | |
| SCHEMBL3380191 | 0.85 | HRH3 (0.49) | HRH3KCNH2POLBMEN1KMT2A | |
| SCHEMBL4649156 | 0.85 | HRH3 (0.43) | HRH3HRH1CCR3KCNH2POLB | |
| SCHEMBL3378456 | 0.82 | HRH3 (0.39) | HRH3SOS1HRH1CCR3KCNH2 | |
| SCHEMBL3416630 | 0.82 | SOS1 (0.35) | HRH3SOS1HRH1CCR3KCNH2 | |
| SCHEMBL4648386 | 0.82 | ADRA1A (0.39) | HRH3KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL3430594 | 0.82 | GSK3B (0.45) | HRH3HRH1CCR3KCNH2OPRM1 | |
| SCHEMBL3378079 | 0.81 | HRH3 (0.48) | HRH3SOS1HRH1CCR3KCNH2 | |
| SCHEMBL4646898 | 0.80 | POLB (0.36) | HRH3SOS1HRH1CCR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2008-03-19 | — | — | EP | claimed |
| WO-2006136924-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-12-28 | — | — | WO | claimed |