Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 5/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 5/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4646898 | 0.91 | POLB (0.36) | SOS1HRH3POLBMEN1KMT2A | |
| SCHEMBL4648386 | 0.83 | ADRA1A (0.39) | HRH3POLBMEN1KMT2AEPHX2 | |
| SCHEMBL3409569 | 0.83 | ADRA1A (0.37) | POLBMEN1KMT2ASCN1ASCN5A | |
| SCHEMBL4646695 | 0.82 | HRH3 (0.40) | SOS1HRH3POLBMEN1KMT2A | |
| SCHEMBL3378463 | 0.77 | HRH3 (0.43) | HRH3POLBHRH1CCR3KCNH2 | |
| SCHEMBL3379505 | 0.77 | HRH3 (0.43) | HRH3POLBHRH1CCR3KCNH2 | |
| SCHEMBL3378456 | 0.77 | HRH3 (0.39) | SOS1HRH3POLBHRH1CCR3 | |
| SCHEMBL4649156 | 0.76 | HRH3 (0.43) | HRH3POLBHRH1CCR3KCNH2 | |
| SCHEMBL4648112 | 0.75 | SCN1A (0.39) | POLBMEN1KMT2ASCN1ASCN8A | |
| SCHEMBL4648462 | 0.75 | HTR7 (0.41) | SOS1POLBMEN1KMT2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | disclosed |