Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CCR2 | P41597 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4646463 | 0.85 | HDAC3 (0.44) | KCNH2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4644327 | 0.81 | CCR3 (0.47) | CCR3NPC1 | |
| SCHEMBL3430594 | 0.80 | GSK3B (0.45) | CCR3KCNH2HRH1ALDH1A1GSK3B | |
| SCHEMBL4649156 | 0.79 | HRH3 (0.43) | CCR3KCNH2HRH1BCHEGSK3B | |
| SCHEMBL4648508 | 0.77 | ALDH1A1 (0.40) | KCNH2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4646898 | 0.76 | POLB (0.36) | CCR3KCNH2HRH1NPC1 | |
| SCHEMBL3379505 | 0.75 | HRH3 (0.43) | CCR3KCNH2HRH1ALDH1A1KDM4E | |
| SCHEMBL3378463 | 0.75 | HRH3 (0.43) | CCR3KCNH2HRH1ALDH1A1KDM4E | |
| SCHEMBL3378456 | 0.75 | HRH3 (0.39) | CCR3KCNH2HRH1ALDH1A1KDM4E | |
| SCHEMBL4648701 | 0.75 | P2RX7 (0.45) | CCR3KCNH2HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006136924-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-12-28 | — | — | WO | disclosed |