Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | CCR3 | P51677 | 2/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.34 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | SCN1A | P35498 | 3/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3416630 | 0.91 | SOS1 (0.35) | POLBMEN1KMT2ASOS1KCNH2 | |
| SCHEMBL4646472 | 0.84 | TP53 (0.36) | POLBMEN1KMT2ASCN8ASCN1A | |
| SCHEMBL4646695 | 0.80 | HRH3 (0.40) | POLBMEN1KMT2ASOS1KCNH2 | |
| SCHEMBL4648386 | 0.80 | ADRA1A (0.39) | POLBMEN1KMT2AHRH3 | |
| SCHEMBL4648545 | 0.76 | CCR3 (0.44) | KCNH2HRH1CCR3NPC1 | |
| SCHEMBL3378463 | 0.75 | HRH3 (0.43) | POLBKCNH2HRH1CCR3HRH3 | |
| SCHEMBL3379505 | 0.75 | HRH3 (0.43) | POLBKCNH2HRH1CCR3HRH3 | |
| SCHEMBL3378456 | 0.75 | HRH3 (0.39) | POLBSOS1KCNH2HRH1CCR3 | |
| SCHEMBL3409569 | 0.74 | ADRA1A (0.37) | POLBMEN1KMT2ASCN8ASCN1B | |
| SCHEMBL4649156 | 0.74 | HRH3 (0.43) | POLBKCNH2HRH1CCR3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006136924-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-12-28 | — | — | WO | disclosed |