Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.63 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MMP12 | P39900 | 2/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.56 |
| ▸ | MMP8 | P22894 | 1/20 | 0.56 |
| ▸ | CCKBR | P32239 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 2/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2245265 | 0.89 | L3MBTL1 (0.72) | ADAMTS5ADAMTS4L3MBTL1MMP12MMP2 | |
| SCHEMBL2249357 | 0.88 | NPC1 (0.67) | ADAMTS5ADAMTS4L3MBTL1MMP12MMP2 | |
| SCHEMBL2247366 | 0.87 | ADAMTS5 (0.61) | ADAMTS5ADAMTS4L3MBTL1MMP12MMP2 | |
| SCHEMBL2250363 | 0.87 | L3MBTL1 (0.62) | ADAMTS5ADAMTS4L3MBTL1MMP12MMP2 | |
| SCHEMBL2244204 | 0.86 | L3MBTL1 (0.61) | ADAMTS5ADAMTS4L3MBTL1MMP12MMP2 | |
| SCHEMBL2246740 | 0.86 | CCKBR (0.70) | ADAMTS5ADAMTS4L3MBTL1MMP12MMP2 | |
| SCHEMBL2247413 | 0.85 | ADAMTS5 (0.60) | ADAMTS5ADAMTS4L3MBTL1MMP12MMP2 | |
| SCHEMBL2245074 | 0.85 | ADAMTS5 (0.60) | ADAMTS5ADAMTS4L3MBTL1MMP12MMP2 | |
| SCHEMBL2246984 | 0.85 | L3MBTL1 (0.60) | ADAMTS5ADAMTS4L3MBTL1MMP12MMP2 | |
| SCHEMBL2247187 | 0.85 | L3MBTL1 (0.60) | ADAMTS5ADAMTS4L3MBTL1MMP12MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | disclosed |