SCHEMBL4648753

SCHEMBL4648753

Cc1ccc(C)n1-c1cc(Cl)ccn1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.39
LMNA P02545 2/20 0.39
ATM Q13315 1/20 0.39
MYC P01106 2/20 0.39
NR4A1 P22736 1/20 0.39
MAP3K14 Q99558 1/20 0.38
KDM4E B2RXH2 3/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
KMT2A Q03164 1/20 0.36
CCR1 P32246 1/20 0.35
CCR5 P51681 1/20 0.35
CCR8 P51685 1/20 0.35
GRM5 P41594 2/20 0.35
MAT2A P31153 1/20 0.35
MAPT P10636 1/20 0.34
RXRA P19793 1/20 0.34
RXRB P28702 1/20 0.34
RXRG P48443 1/20 0.34
NPC1 O15118 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6619720 0.79 ALDH1A1 (0.57) ALDH1A1LMNAKDM4EL3MBTL1KMT2A
SCHEMBL3560036 0.76 KDM4E (0.47) ALDH1A1LMNAMYCNR4A1KDM4E
SCHEMBL30839382 0.73 CCR1 (0.52) ALDH1A1LMNAKDM4ECCR1CCR5
SCHEMBL18586126 0.73 ALDH1A1 (0.51) ALDH1A1LMNAMYCKDM4EL3MBTL1
SCHEMBL29187159 0.72 LCK (0.43) ALDH1A1LMNAMYCNR4A1KDM4E
SCHEMBL31338775 0.72 MYC (0.35) ALDH1A1LMNAMYCNR4A1KDM4E
SCHEMBL30001069 0.72 LCK (0.43) ALDH1A1LMNAMYCNR4A1KDM4E
SCHEMBL8499852 0.72 KDR (0.46) ALDH1A1ATMMAP3K14GRM5
Isopropyl Alcohol SCHEMBL6839921 0.72 ALDH1A1 (0.50) ALDH1A1LMNAKDM4EL3MBTL1KMT2A
SCHEMBL4593796 0.72 RECQL (0.47) ALDH1A1LMNAKDM4EL3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016007837-A1 CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS SPERO THERAPEUTICS, INC. (US) 2016-01-14 WO disclosed
WO-2016007837-A1 CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS SPERO THERAPEUTICS, INC. (US) 2016-01-14 WO disclosed
EP-1960394-A2 PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER Bayer HealthCare AG (DE) 2008-08-27 EP disclosed
WO-2007059202-A2 PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER BAYER HEALTHCARE AG (DE) 2007-05-24 WO disclosed
WO-2007059202-A2 PYRAZOLYL UREA DERIVATIVES USEFUL IN THE TREATMENT OF CANCER BAYER HEALTHCARE AG (DE) 2007-05-24 WO disclosed