Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | VHL | P40337 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SORD | Q00796 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 2/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13040670 | 0.86 | ALDH1A1 (0.35) | RECQLALDH1A1LMNASORDKDM4E | |
| SCHEMBL18585998 | 0.82 | ALDH1A1 (0.36) | ALDH1A1LMNAKDM4EKDM5ALOXL2 | |
| SCHEMBL13040657 | 0.81 | ALDH1A1 (0.36) | RECQLALDH1A1LMNAKDM4EKDM5A | |
| SCHEMBL18586168 | 0.79 | KLKB1 (0.38) | ALDH1A1LMNASORDKDM4EKLKB1 | |
| SCHEMBL4334724 | 0.78 | KDM4E (0.41) | ALDH1A1LMNAKDM4ELOXL2L3MBTL1 | |
| Propanol SCHEMBL6771763 | 0.76 | ALDH1A1 (0.48) | RECQLALDH1A1LMNAKDM4EL3MBTL1 | |
| SCHEMBL6619720 | 0.75 | ALDH1A1 (0.57) | RECQLALDH1A1LMNAKDM4EL3MBTL1 | |
| SCHEMBL17781654 | 0.74 | RECQL (0.50) | RECQLVHLMAOADYRK1AHRH3 | |
| SCHEMBL22898276 | 0.74 | SORD (0.53) | RECQLHRH3SORD | |
| SCHEMBL4594579 | 0.73 | AKT1 (0.36) | HRH3ALDH1A1LMNAKDM5AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891047-A4 | 1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS | BAYER HEALTHCARE AG (DE) | 2008-07-09 | — | — | EP | disclosed |
| EP-1891047-A2 | 1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS | Bayer HealthCare AG (DE) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006133006-A2 | 1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS | BAYER HEALTHCARE AG (DE) | 2006-12-14 | — | — | WO | disclosed |