Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | APEX1 | P27695 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.30 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.30 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.30 |
| ▸ | C1S | P09871 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL17967024 | 0.94 | HRH4 (0.35) | HRH4NOS2MAPK1NOS3NOS1 | |
| Guanidine SCHEMBL17184362 | 0.94 | NOS2 (0.39) | HRH4NOS2MAPK1NOS3NOS1 | |
| Guanidine SCHEMBL5053878 | 0.94 | NOS2 (0.39) | HRH4NOS2MAPK1NOS3NOS1 | |
| Guanidine SCHEMBL29088714 | 0.94 | NOS2 (0.39) | HRH4NOS2MAPK1NOS3NOS1 | |
| Guanidine SCHEMBL2453389 | 0.94 | — | — | |
| Guanidine SCHEMBL19610646 | 0.94 | NOS2 (0.39) | HRH4NOS2MAPK1NOS3NOS1 | |
| Guanidine SCHEMBL3349156 | 0.94 | — | — | |
| Guanidine SCHEMBL8024162 | 0.94 | — | — | |
| Guanidine SCHEMBL2340600 | 0.94 | — | — | |
| Guanidine SCHEMBL395351 | 0.94 | NOS2 (0.39) | HRH4NOS2MAPK1NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960408-A1 | PROCESS FOR THE PRODUCTION OF MERCAPTOALKYLALKOXYSILANES | Momentive Performance Materials Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1869057-A2 | AQUEOUS CATALYTIC PROCESS FOR THE PREPARATION OF THIOCARBOXYLATE SILANE | General Electric Company (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2007058979-A1 | PROCESS FOR THE PRODUCTION OF MERCAPTOALKYLALKOXYSILANES | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2006113122-A2 | AQUEOUS CATALYTIC PROCESS FOR THE PREPARATION OF THIOCARBOXYLATE SILANE | GENERAL ELECTRIC COMPANY (US) | 2006-10-26 | — | — | WO | disclosed |