Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 5/20 | 0.37 |
| ▸ | NOS1 | P29475 | 4/20 | 0.37 |
| ▸ | NOS3 | P29474 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4647964 | 0.89 | EPHX2 (0.40) | EPHX2HDAC2NOS2NOS1NOS3 | |
| SCHEMBL4648881 | 0.87 | HDAC2 (0.43) | EPHX2HDAC2NOS2NOS1NOS3 | |
| SCHEMBL4647377 | 0.85 | MAPT (0.46) | EPHX2NOS2NOS1NOS3LMNA | |
| SCHEMBL4647781 | 0.84 | ALDH1A1 (0.47) | EPHX2HDAC2MAPK1HTTCDK2 | |
| SCHEMBL4647277 | 0.80 | HDAC2 (0.43) | EPHX2HDAC2NOS2NOS1NOS3 | |
| SCHEMBL4647104 | 0.79 | HDAC2 (0.43) | HDAC2NOS2NOS1NOS3LMNA | |
| SCHEMBL4649493 | 0.78 | NOS2 (0.40) | HDAC2NOS2NOS1NOS3LMNA | |
| SCHEMBL4647407 | 0.78 | NOS2 (0.44) | HDAC2NOS2NOS1NOS3LMNA | |
| SCHEMBL4750123 | 0.78 | NOS2 (0.44) | HDAC2NOS2NOS1NOS3LMNA | |
| SCHEMBL4659793 | 0.78 | NOS2 (0.50) | HDAC2NOS2NOS1NOS3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960389-A2 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007036718-A2 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |