Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 5/20 | 0.44 |
| ▸ | NOS1 | P29475 | 4/20 | 0.44 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4647407 | 0.96 | NOS2 (0.44) | NOS2NOS1NOS3KITUSP2 | |
| SCHEMBL4646712 | 0.88 | MAPT (0.43) | NOS2NOS1NOS3KITSMN1; SMN2 | |
| SCHEMBL4647277 | 0.88 | HDAC2 (0.43) | NOS2NOS1NOS3USP2NPSR1 | |
| SCHEMBL4647178 | 0.87 | NOS2 (0.40) | NOS2NOS1NOS3KITUSP2 | |
| SCHEMBL4648472 | 0.87 | CDK1 (0.44) | NOS2NOS1NOS3USP2NPSR1 | |
| SCHEMBL4647104 | 0.87 | HDAC2 (0.43) | NOS2NOS1NOS3KITUSP2 | |
| SCHEMBL4649493 | 0.86 | NOS2 (0.40) | NOS2NOS1NOS3USP2NPSR1 | |
| SCHEMBL4646792 | 0.85 | KDM1A (0.42) | NOS2NOS1NOS3USP2NPSR1 | |
| SCHEMBL4636122 | 0.84 | NOS2 (0.50) | NOS2NOS1NOS3KITALDH1A1 | |
| SCHEMBL4750089 | 0.84 | MAPT (0.51) | NOS2NOS1NOS3KITALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119721-A1 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |