SCHEMBL4649159

SCHEMBL4649159

OC(C#Cc1ccc(N2CCCCC2)cc1)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.51
HTT P42858 1/20 0.51
MAPK1 P28482 1/20 0.49
NPC1 O15118 4/20 0.45
MAPT P10636 4/20 0.45
KMT2A Q03164 3/20 0.45
USP2 O75604 1/20 0.45
ESR1 P03372 1/20 0.45
NR4A1 P22736 1/20 0.45
PTK2B Q14289 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
SMN1; SMN2 Q16637 3/20 0.43
RAB9A P51151 3/20 0.43
GAA P10253 2/20 0.43
TP53 P04637 2/20 0.43
KDM4E B2RXH2 2/20 0.43
LMNA P02545 1/20 0.43
HPGD P15428 1/20 0.43
ALOX15 P16050 1/20 0.43
TSHR P16473 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3951909 0.98 ALDH1A1 (0.50) ALDH1A1HTTMAPK1NPC1MAPT
SCHEMBL8350349 0.94 ALDH1A1 (0.48) ALDH1A1HTTMAPK1NPC1MAPT
SCHEMBL3996471 0.93 ALDH1A1 (0.47) ALDH1A1HTTMAPK1NPC1MAPT
SCHEMBL4649145 0.87 LMNA (0.49) ALDH1A1HTTMAPK1NPC1MAPT
SCHEMBL4650829 0.86 NPC1 (0.49) ALDH1A1HTTMAPK1NPC1MAPT
SCHEMBL7734103 0.82 MAPT (0.46) ALDH1A1MAPK1NPC1MAPTKMT2A
SCHEMBL8358624 0.81 GRM5 (0.51) ALDH1A1HTTMAPK1NPC1MAPT
SCHEMBL7053252 0.81 IGF1R (0.45) ALDH1A1MAPK1NPC1MAPTKMT2A
SCHEMBL4051082 0.79 HIF1A (0.50) ALDH1A1MAPK1NPC1MAPTKMT2A
SCHEMBL2519799 0.77 TSHR (0.52) ALDH1A1HTTMAPK1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1963896-A1 PHOTOCHROMIC MATERIALS HAVING ELECTRON-WITHDRAWING SUBSTITUENTS TRANSITIONS OPTICAL, INC. (US) 2008-09-03 EP disclosed
WO-2007073462-A1 PHOTOCHROMIC MATERIALS HAVING ELECTRON-WITHDRAWING SUBSTITUENTS TRANSITIONS OPTICAL, INC. (US) 2007-06-28 WO disclosed
EP-1117656-A1 GREY COLOURING PHOTOCHROMIC FUSED PYRANS JAMES ROBINSON LIMITED (GB) 2001-07-25 EP disclosed
WO-2000018755-A1 GREY COLOURING PHOTOCHROMIC FUSED PYRANS JAMES ROBINSON LIMITED (GB) 2000-04-06 WO disclosed