Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358624 | 0.94 | GRM5 (0.51) | LMNAGRM5ACP1PKMTSHR | |
| SCHEMBL3951909 | 0.88 | ALDH1A1 (0.50) | LMNAPKMTSHRMEN1KMT2A | |
| SCHEMBL4649159 | 0.87 | ALDH1A1 (0.51) | LMNAPKMTSHRMEN1KMT2A | |
| SCHEMBL4649497 | 0.86 | KDM4E (0.46) | LMNAGRM5MEN1KMT2AALDH1A1 | |
| SCHEMBL163754 | 0.83 | MAPT (0.49) | MEN1KMT2AALDH1A1MAPTRAB9A | |
| SCHEMBL1821168 | 0.83 | MAPT (0.49) | MEN1KMT2AALDH1A1MAPTRAB9A | |
| SCHEMBL3996471 | 0.82 | ALDH1A1 (0.47) | LMNAGRM5PKMTSHRMEN1 | |
| SCHEMBL8350349 | 0.81 | ALDH1A1 (0.48) | LMNAGRM5PKMTSHRKMT2A | |
| SCHEMBL1819239 | 0.80 | MAPT (0.41) | MEN1KMT2AALDH1A1ACACBMAPT | |
| SCHEMBL1820200 | 0.78 | ACACB (0.38) | LMNAALDH1A1ACACBMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313996-A1 | INDENONAPHTHOPYRANS HAVING TRIALKYLSILYL AND ETHYLENICALLY UNSATURATED GROUPS | Transitions Optical, Ltd. (IE) | 2024-02-07 | — | — | EP | disclosed |
| CN-107253943-B | Photochromic compounds and compositions | 光学转变公司 | 2022-05-17 | — | — | CN | disclosed |
| EP-2651912-B1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | TRANSITIONS OPTICAL INC (US) | 2018-10-03 | — | — | EP | disclosed |
| US-9034219-B2 | Photochromic compounds and compositions | TRANSITIONS OPTICAL, INC. (US) | 2015-05-19 | — | — | US | disclosed |
| EP-2651914-B1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | TRANSITIONS OPTICAL INC (US) | 2015-05-13 | — | — | EP | disclosed |
| EP-2651914-A1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | Transitions Optical, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012082999-A1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | WO | disclosed |
| US-20120156521-A1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| EP-1963896-A1 | PHOTOCHROMIC MATERIALS HAVING ELECTRON-WITHDRAWING SUBSTITUENTS | TRANSITIONS OPTICAL, INC. (US) | 2008-09-03 | — | — | EP | disclosed |
| EP-1872159-A1 | OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS | Johnson and Johnson Vision Care, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1866699-A1 | PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS | TRANSITIONS OPTICAL, INC. (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2007073462-A1 | PHOTOCHROMIC MATERIALS HAVING ELECTRON-WITHDRAWING SUBSTITUENTS | TRANSITIONS OPTICAL, INC. (US) | 2007-06-28 | — | — | WO | disclosed |
| WO-2006110520-A1 | OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2006-10-19 | — | — | WO | disclosed |
| WO-2006110219-A1 | PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS | TRANSITIONS OPTICAL, INC. (US) | 2006-10-19 | — | — | WO | disclosed |
| EP-1265885-A2 | HYDROXYLATED/CARBOXYLATED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001070719-A2 | HYDROXYLATED/CARBOXYLATED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2001-09-27 | — | — | WO | disclosed |
| EP-1097156-A2 | PHTOCHROMIC BENZOPYRANO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000002884-A2 | PHOTOCHROMIC BENZOPYRANO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2000-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120156521-A1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | CRY2, CRY1, PPOX | LMNA 657/4885GRM5 3559/4885ACP1 847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.