Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4647324 | 0.84 | ALDH1A1 (0.51) | KDM5AKDM5BCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL4649345 | 0.81 | PARP4 (0.37) | KDM4EPARP4 | |
| SCHEMBL5810858 | 0.80 | KDM4E (0.42) | KDM5AKDM5BALDH1A1KDM4ELMNA | |
| SCHEMBL4801279 | 0.76 | KMT2A (0.39) | KDM5AALDH1A1KDM4ELMNA | |
| SCHEMBL4649141 | 0.75 | ALDH1A1 (0.40) | KDM5AALDH1A1KDM4E | |
| SCHEMBL6198339 | 0.72 | KDM5A (0.48) | KDM5AKDM5BCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL8258156 | 0.72 | PARP4 (0.38) | ALDH1A1KDM4EPARP4LMNA | |
| SCHEMBL27397917 | 0.66 | CYP2C9 (0.41) | CYP2C9CYP2C19NPSR1ALDH1A1KDM4E | |
| SCHEMBL2384086 | 0.65 | ALDH1A1 (0.49) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL13312806 | 0.63 | KDM5A (0.59) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960363-A2 | QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | Amgen, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007070359-A2 | QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMGEN INC. (US) | 2007-06-21 | — | — | WO | disclosed |
| WO-2006089689-A1 | 2-QUINOLONE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASES | GLAXO GROUP LIMITED (GB) | 2006-08-31 | — | — | WO | disclosed |