Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4801279 | 0.91 | KMT2A (0.39) | ALDH1A1KDM4EGAAKMT2AHSD17B10 | |
| SCHEMBL4648398 | 0.87 | ALDH1A1 (0.40) | ALDH1A1KDM4EGAAKMT2ASMN1; SMN2 | |
| SCHEMBL4649368 | 0.84 | SMN1; SMN2 (0.42) | ALDH1A1KDM4EGAAKMT2ASMN1; SMN2 | |
| SCHEMBL4649688 | 0.83 | KDM4E (0.44) | ALDH1A1KDM4EGAAKMT2ASMN1; SMN2 | |
| SCHEMBL4647324 | 0.83 | ALDH1A1 (0.51) | ALDH1A1KDM4EGAAKMT2ASMN1; SMN2 | |
| SCHEMBL4799223 | 0.79 | HIF1A (0.41) | ALDH1A1KDM4EKMT2ASMN1; SMN2POLB | |
| SCHEMBL4649345 | 0.76 | PARP4 (0.37) | KDM4EGAAMAPTHSD17B10HPGD | |
| SCHEMBL4649252 | 0.75 | GABRG2 (0.38) | ALDH1A1KDM4EKDM5A | |
| SCHEMBL5308580 | 0.73 | HIF1A (0.46) | ALDH1A1KDM4EKMT2AMAPTHSD17B10 | |
| SCHEMBL6198339 | 0.71 | KDM5A (0.48) | ALDH1A1KDM4EGAAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960363-A2 | QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | Amgen, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007070359-A2 | QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMGEN INC. (US) | 2007-06-21 | — | — | WO | disclosed |