Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pefloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.90 |
| ▸ | HPGD | P15428 | 3/20 | 0.90 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.90 |
| ▸ | LMNA | P02545 | 2/20 | 0.90 |
| ▸ | TSHR | P16473 | 2/20 | 0.90 |
| ▸ | HTT | P42858 | 2/20 | 0.90 |
| ▸ | BRD4 | O60885 | 1/20 | 0.90 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.90 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.90 |
| ▸ | DRD3 | P35462 | 1/20 | 0.88 |
| ▸ | MEN1 | O00255 | 8/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.80 |
| ▸ | NPC1 | O15118 | 1/20 | 0.80 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | RAD52 | P43351 | 1/20 | 0.71 |
| ▸ | GLA | P06280 | 1/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norfloxacin SCHEMBL27395494 | 0.95 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL3473 | 0.95 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL2221304 | 0.95 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL10886039 | 0.94 | ALDH1A1 (0.98) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL3147077 | 0.94 | ALDH1A1 (0.98) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL9788079 | 0.94 | ALDH1A1 (0.98) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL28495826 | 0.94 | ALDH1A1 (0.98) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL11524201 | 0.94 | ALDH1A1 (0.98) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL10911469 | 0.94 | ALDH1A1 (0.98) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Norfloxacin SCHEMBL28112643 | 0.94 | ALDH1A1 (0.98) | KDM4EALDH1A1HPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022038645-A1 | NOVEL SUBSTITUTED QUINOLONE DERIVATIVES, METHODS OF PREPARATION THEREOF, AND THEIR USE FOR TREAING MICROBIAL INFECTIONS | THE UNIVERSITY OF JORDAN (JO) | 2022-02-24 | — | — | WO | disclosed |
| EP-1962861-A2 | COMPOUNDS AND METHODS FOR MODULATING THE SILENCING OF A POLYNUCLEOTIDE OF INTEREST | Emory University (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007025187-A2 | COMPOUNDS AND METHODS FOR MODULATING THE SILENCING OF A POLYNUCLEOTIDE OF INTEREST | EMORY UNIVERSITY (US) | 2007-03-01 | — | — | WO | disclosed |
| EP-1401440-A4 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST BACTERIA | LG LIFE SCIENCES LTD (KR) | 2006-07-05 | — | — | EP | disclosed |
| EP-1401440-A1 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST BACTERIA | Smithkline Beecham (US) | 2004-03-31 | — | — | EP | disclosed |
| WO-2001015695-A1 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST BACTERIA | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-08 | — | — | WO | disclosed |
| CN-1039358-A | Antibiotic synergistic pharmaceutical combination and preparation method thereof | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1990-02-07 | — | — | CN | disclosed |