Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | DNA2 | P51530 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650054 | 0.89 | CSNK2A2 (0.48) | ALDH1A1HPGDCYP1A2CSNK2A2CSNK2B | |
| SCHEMBL17769720 | 0.88 | CSNK2A2 (0.49) | ALDH1A1HPGDCYP1A2CSNK2A2CSNK2B | |
| SCHEMBL4650129 | 0.87 | CSNK2A2 (0.42) | ALDH1A1HPGDCYP1A2MEN1ALOX12 | |
| SCHEMBL4650802 | 0.83 | ALDH1A1 (0.53) | ALDH1A1HPGDCYP1A2MEN1ALOX12 | |
| SCHEMBL5324021 | 0.81 | LMNA (0.35) | ALDH1A1 | |
| SCHEMBL5326042 | 0.80 | HPGD (0.42) | ALDH1A1HPGDCYP1A2MEN1ALOX12 | |
| SCHEMBL5303400 | 0.79 | ALDH1A1 (0.52) | ALDH1A1HPGDCYP1A2MEN1ALOX12 | |
| SCHEMBL5194351 | 0.79 | CSNK2A2 (0.50) | ALDH1A1HPGDCYP1A2MEN1ALOX12 | |
| SCHEMBL3812191 | 0.78 | CSNK2A2 (0.49) | ALDH1A1HPGDCYP1A2MEN1ALOX12 | |
| SCHEMBL17769482 | 0.76 | CSNK2A2 (0.47) | ALDH1A1HPGDCYP1A2MEN1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | claimed |
| EP-1963271-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | disclosed |