Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.42 |
| ▸ | MDH2 | P40926 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HAT1 | O14929 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4649429 | 0.87 | ALDH1A1 (0.49) | CSNK2A2CSNK2BCSNK2A1ALDH1A1HPGD | |
| SCHEMBL4650054 | 0.87 | CSNK2A2 (0.48) | CSNK2A2CSNK2BCSNK2A1MDH2ALDH1A1 | |
| SCHEMBL17769720 | 0.85 | CSNK2A2 (0.49) | CSNK2A2CSNK2BCSNK2A1MDH2ALDH1A1 | |
| SCHEMBL4649277 | 0.84 | ALDH1A1 (0.41) | MDH2ALDH1A1HPGDSMN1; SMN2HAT1 | |
| SCHEMBL4650001 | 0.77 | CSNK2A2 (0.39) | CSNK2A2CSNK2BCSNK2A1MDH2AKR1C2 | |
| SCHEMBL5194351 | 0.76 | CSNK2A2 (0.50) | CSNK2A2CSNK2BCSNK2A1ALDH1A1HPGD | |
| SCHEMBL4649431 | 0.76 | MDH2 (0.52) | MDH2ALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL4650158 | 0.76 | GABRA1 (0.58) | MDH2ALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL3812191 | 0.75 | CSNK2A2 (0.49) | CSNK2A2CSNK2BCSNK2A1ALDH1A1HPGD | |
| SCHEMBL4650110 | 0.75 | KDM5A (0.42) | MDH2ALDH1A1HPGDSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | claimed |