SCHEMBL4649646

SCHEMBL4649646

COc1cccc2oc(-c3ccccc3)c(O)c(=O)c12

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 10/20 0.67
CYP3A4 P08684 10/20 0.67
MEN1 O00255 7/20 0.67
KMT2A Q03164 7/20 0.67
MAPT P10636 7/20 0.67
TP53 P04637 6/20 0.67
HSD17B10 Q99714 6/20 0.67
HPGD P15428 6/20 0.67
LMNA P02545 4/20 0.67
MAPK1 P28482 3/20 0.67
ALOX15 P16050 2/20 0.67
USP2 O75604 1/20 0.67
CYP1B1 Q16678 3/20 0.60
CYP1A1 P04798 2/20 0.60
CYP1A2 P05177 2/20 0.60
ABCG2 Q9UNQ0 4/20 0.59
ALDH1A1 P00352 6/20 0.58
GAA P10253 1/20 0.58
CA12 O43570 2/20 0.57
ABCB1 P08183 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31675988 1.00 KDM4E (0.67) KDM4ECYP3A4MEN1KMT2AMAPT
SCHEMBL6666764 0.86 CYP1B1 (0.60) KDM4ECYP3A4MEN1KMT2AMAPT
SCHEMBL380907 0.85 ADORA3 (0.73) KDM4ECYP3A4MEN1KMT2AMAPT
SCHEMBL5133662 0.85 NOX4 (0.73) KDM4ECYP3A4MEN1KMT2AMAPT
SCHEMBL7660030 0.84 NOX4 (0.76) KDM4ECYP3A4MEN1KMT2AMAPT
SCHEMBL38650680 0.84 ABCG2 (0.83) KDM4ECYP3A4MEN1KMT2AMAPT
SCHEMBL28536757 0.84 ABCG2 (0.83) KDM4ECYP3A4MEN1KMT2AMAPT
SCHEMBL21581945 0.83 ABCG2 (0.60) KDM4ECYP3A4MEN1KMT2AMAPT
SCHEMBL5964713 0.83 KDM4E (0.62) KDM4ECYP3A4MEN1KMT2AMAPT
SCHEMBL28757172 0.83 ADORA3 (0.60) KDM4ECYP3A4MEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109336469-B SBS modified asphalt mixture and preparation method thereof 湖北津泰环保科技有限公司 2021-06-08 CN claimed
CN-101898967-A Synthesis method of 5-methoxyflavonol CINKATE PHARMACEUTICAL CHEMICAL INTERMEDIATES SHANGHAI CO LTD 2010-12-01 CN claimed
CN-1837202-B Flavonols with blood-fat-lowering effect UNIV PLA 2ND MILITARY MEDICAL 2010-08-18 CN claimed
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 US claimed
JP-2003504327-A 2003-02-04 JP claimed
EP-1223928-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS Prendergast, Patrick Thomas (IE) 2002-07-24 EP claimed
WO-2001003681-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS PRENDERGAST PATRICK T (IE) 2001-01-18 WO claimed
US-5626883-A VITAMIN C SUPPLEMENTS FOR IMMUNOLOGY METAGENICS, INC. 1997-05-06 US claimed
EP-4536210-A2 FLAVONOID COMPOUNDS AND METHODS AND MATERIALS FOR USING FLAVONOID COMPOUNDS TO TREAT FIBROTIC CONDITIONS Mayo Foundation for Medical Education and Research (US) 2025-04-16 EP disclosed
WO-2023244619-A2 FLAVONOID COMPOUNDS AND METHODS AND MATERIALS FOR USING FLAVONOID COMPOUNDS TO TREAT FIBROTIC CONDITIONS MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2023-12-21 WO disclosed
CN-113072527-B Potato ring rot pathogen resistant quercetin derivative and synthesis method and application thereof 山西大学 2023-03-10 CN disclosed
CN-110446486-B Novel antioxidants for cosmetic and pharmaceutical compositions containing glycerol alkyl ethers 赛成公司 2022-08-30 CN disclosed
CN-113072527-A Potato ring rot pathogen resistant quercetin derivative and synthesis method and application thereof 山西大学 2021-07-06 CN disclosed
CN-109336469-B SBS modified asphalt mixture and preparation method thereof 湖北津泰环保科技有限公司 2021-06-08 CN disclosed
US-20030125264-A1 Methods For Treating Wounds KIMBERLY-CLARK WORLDWIDE, INC. 2003-07-03 US disclosed
US-6555523-B1 Such as 3',4'-diacetoxy-5,6,7-trimethoxyflavone or naringin in the treatment HIV, picornavirus, and/or respiratory virus CASCADE ESTATES LTD. (MU) 2003-04-29 US disclosed
EP-1223928-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS Prendergast, Patrick Thomas (IE) 2002-07-24 EP disclosed
WO-2001003681-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS PRENDERGAST PATRICK T (IE) 2001-01-18 WO disclosed
US-5626883-A VITAMIN C SUPPLEMENTS FOR IMMUNOLOGY METAGENICS, INC. 1997-05-06 US disclosed
WO-1995028084-A1 ASCORBIC ACID COMPOSITION PROVIDING ENHANCED HUMAN IMMUNE SYSTEM ACTIVITY METAGENICS, INC. (US) 1995-10-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030125264-A1 Methods For Treating Wounds FGF2, MMP1, FIBP KDM4E 2309/4885CYP3A4 3010/4885MEN1 3867/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.