Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.77 |
| ▸ | MAPT | P10636 | 8/20 | 0.76 |
| ▸ | MEN1 | O00255 | 7/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.76 |
| ▸ | TP53 | P04637 | 7/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.76 |
| ▸ | CASP1 | P29466 | 6/20 | 0.76 |
| ▸ | CASP7 | P55210 | 6/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.76 |
| ▸ | HPGD | P15428 | 6/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.76 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | RECQL | P46063 | 2/20 | 0.65 |
| ▸ | CD38 | P28907 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29870196 | 0.92 | ABCB1 (0.81) | ABCB1MAPTMEN1KMT2ATP53 | |
| SCHEMBL5432990 | 0.89 | ABCG2 (0.78) | ABCB1MAPTMEN1KMT2ATP53 | |
| SCHEMBL4035471 | 0.88 | MAPT (0.65) | ABCB1MAPTMEN1KMT2ATP53 | |
| SCHEMBL4650613 | 0.87 | ABCB1 (1.00) | ABCB1MAPTMEN1KMT2ATP53 | |
| SCHEMBL31675757 | 0.87 | ABCB1 (1.00) | ABCB1MAPTMEN1KMT2ATP53 | |
| Geraldol SCHEMBL29394734 | 0.86 | MEN1 (1.00) | ABCB1MAPTMEN1KMT2ATP53 | |
| Geraldol SCHEMBL620712 | 0.86 | MEN1 (1.00) | ABCB1MAPTMEN1KMT2ATP53 | |
| Geraldol SCHEMBL31122383 | 0.86 | MEN1 (1.00) | ABCB1MAPTMEN1KMT2ATP53 | |
| SCHEMBL4649257 | 0.86 | KDM4E (0.77) | ABCB1MAPTMEN1KMT2ATP53 | |
| SCHEMBL3339525 | 0.85 | MAPT (0.63) | ABCB1MAPTMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872771-B1 | Tire with rubber containing flavone | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2005-03-29 | — | — | US | claimed |
| US-20040242503-A1 | Compositions comprising blockers of l-dopa renal cell transfer for the treatment of parkinson's disease | ATTENTION LABS INCORPORATED | 2004-12-02 | — | — | US | claimed |
| EP-1267853-B1 | COMPOSITIONS COMPRISING BLOCKERS OF L-DOPA RENAL CELL TRANSFER FOR THE TREATMENT OF PARKINSON'S DISEASE | PORTELA & CA SA (PT) | 2004-09-08 | — | — | EP | claimed |
| EP-1267853-A2 | COMPOSITIONS COMPRISING BLOCKERS OF L-DOPA RENAL CELL TRANSFER FOR THE TREATMENT OF PARKINSON'S DISEASE | Portela & Ca., S.A. (PT) | 2003-01-02 | — | — | EP | claimed |
| WO-2001068065-A9 | COMPOSITIONS COMPRISING BLOCKERS OF L-DOPA RENAL CELL TRANSFER FOR THE TREATMENT OF PARKINSON'S DISEASE | PORTELA & CA SA (PT) | 2002-07-18 | — | — | WO | claimed |
| WO-2001068065-A2 | COMPOSITIONS COMPRISING BLOCKERS OF L-DOPA RENAL CELL TRANSFER FOR THE TREATMENT OF PARKINSON'S DISEASE | PORTELA & COMPANHIA S.A. (PT) | 2001-09-20 | — | — | WO | claimed |
| EP-2730431-B1 | Rubber composition and tire with rubber containing flavone | GOODYEAR TIRE & RUBBER (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2730431-A1 | Rubber composition and tire with rubber containing flavone | The Goodyear Tire & Rubber Company (US) | 2014-05-14 | — | — | EP | disclosed |
| WO-2009026657-A1 | FLAVONOID PPAR AGONISTS | THE UNIVERSITY OF SYDNEY (AU) | 2009-03-05 | — | — | WO | disclosed |
| EP-1391327-B1 | Tire with rubber containing flavone | GOODYEAR TIRE & RUBBER (US) | 2008-09-03 | — | — | EP | disclosed |
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | EASTMAN CHEMICAL COMPANY | 2007-11-01 | — | — | US | disclosed |
| US-7129269-B2 | Sulphamate compounds for inhibiting oestrone sulphatase activity and aromatase activity; anticarcinogenic agents | STERIX LTD. (GB) | 2006-10-31 | — | — | US | disclosed |
| US-6872771-B1 | Tire with rubber containing flavone | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2005-03-29 | — | — | US | disclosed |
| EP-1391327-A1 | Tire with rubber containing flavone | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2004-02-25 | — | — | EP | disclosed |
| US-6506792-B1 | Breast and endometrial cancers are major causes of death in Western women. In particular, tumours in endocrine-dependent tissues, such as the breast and endometrium, occur most frequently in postmenopausal women at a time when the ovaries | STERIX LIMITED (GB) | 2003-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | ABCC4, NCOA4, NR4A3 | ABCB1 59/4885MAPT 4566/4885MEN1 4281/4885 |
| US-20040242503-A1 | Compositions comprising blockers of l-dopa renal cell transfer for the treatment of parkinson's disease | COMT, DDC, AADAT | ABCB1 54/4885MAPT 1243/4885MEN1 3883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.