Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.76 |
| ▸ | HPGD | P15428 | 2/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.76 |
| ▸ | CYP1A1 | P04798 | 10/20 | 0.70 |
| ▸ | CYP1B1 | Q16678 | 10/20 | 0.70 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.70 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.70 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.70 |
| ▸ | AHR | P35869 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | PRKDC | P78527 | 2/20 | 0.66 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.65 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.65 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.65 |
| ▸ | PDE5A | O76074 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 8,2'-Dimethoxyflavone SCHEMBL516353 | 0.86 | ALDH1A1 (1.00) | CYP3A4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL6616218 | 0.83 | CYP3A4 (0.73) | CYP3A4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL7374618 | 0.83 | ALDH1A1 (0.82) | CYP3A4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL4650074 | 0.82 | ABCG2 (1.00) | CYP3A4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL29361605 | 0.82 | ABCG2 (1.00) | CYP3A4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL7160712 | 0.82 | AHR (1.00) | CYP3A4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL31060597 | 0.80 | CYP1A1 (1.00) | CYP3A4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL14708633 | 0.79 | CSNK2A2 (1.00) | CYP3A4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL253522 | 0.79 | HPGD (0.78) | CYP3A4KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL4650874 | 0.79 | CYP1A1 (1.00) | CYP3A4KDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872771-B1 | Tire with rubber containing flavone | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2005-03-29 | — | — | US | claimed |
| EP-2730431-B1 | Rubber composition and tire with rubber containing flavone | GOODYEAR TIRE & RUBBER (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2730431-A1 | Rubber composition and tire with rubber containing flavone | The Goodyear Tire & Rubber Company (US) | 2014-05-14 | — | — | EP | disclosed |
| EP-1391327-B1 | Tire with rubber containing flavone | GOODYEAR TIRE & RUBBER (US) | 2008-09-03 | — | — | EP | disclosed |
| US-6872771-B1 | Tire with rubber containing flavone | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2005-03-29 | — | — | US | disclosed |
| EP-1391327-A1 | Tire with rubber containing flavone | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2004-02-25 | — | — | EP | disclosed |
| US-6555523-B1 | Such as 3',4'-diacetoxy-5,6,7-trimethoxyflavone or naringin in the treatment HIV, picornavirus, and/or respiratory virus | CASCADE ESTATES LTD. (MU) | 2003-04-29 | — | — | US | disclosed |
| EP-1223928-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | Prendergast, Patrick Thomas (IE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001003681-A2 | USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS | PRENDERGAST PATRICK T (IE) | 2001-01-18 | — | — | WO | disclosed |