SCHEMBL4649969

SCHEMBL4649969

COc1ccc(-c2cc(=O)c3c(OC)c(OC)c(OC)cc3o2)cc1OCc1ccccc1

nearest known ligand 0.73

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 2/20 0.73
MEN1 O00255 2/20 0.73
KMT2A Q03164 2/20 0.73
TP53 P04637 1/20 0.73
MDM2 Q00987 1/20 0.73
ABCG2 Q9UNQ0 1/20 0.73
CYP1A1 P04798 3/20 0.62
CYP1B1 Q16678 2/20 0.62
CYP1A2 P05177 2/20 0.61
OPRD1 P41143 1/20 0.61
ALDH1A1 P00352 1/20 0.60
ACHE P22303 2/20 0.58
L3MBTL1 Q9Y468 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8052929 0.98 ABCB1 (0.69) ABCB1MEN1KMT2ATP53MDM2
SCHEMBL7156543 0.98 ABCB1 (0.69) ABCB1MEN1KMT2ATP53MDM2
SCHEMBL24514601 0.96 ABCB1 (0.73) ABCB1MEN1KMT2ATP53MDM2
SCHEMBL8068919 0.96 ABCB1 (0.73) ABCB1MEN1KMT2ATP53MDM2
SCHEMBL8052863 0.95 ABCB1 (0.64) ABCB1MEN1KMT2ATP53MDM2
SCHEMBL21206267 0.94 ABCB1 (0.73) ABCB1MEN1KMT2ATP53MDM2
SCHEMBL30376265 0.94 ABCB1 (0.73) ABCB1MEN1KMT2ATP53MDM2
SCHEMBL24514598 0.93 ABCB1 (0.68) ABCB1MEN1KMT2ATP53MDM2
SCHEMBL8062122 0.90 ABCB1 (0.64) ABCB1MEN1KMT2ATP53MDM2
SCHEMBL738489 0.88 MEN1 (0.71) ABCB1MEN1KMT2ATP53MDM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 US claimed
EP-2730431-B1 Rubber composition and tire with rubber containing flavone GOODYEAR TIRE & RUBBER (US) 2017-06-28 EP disclosed
US-20140135433-A1 TIRE WITH RUBBER CONTAINING FLAVONE THE GOODYEAR TIRE & RUBBER COMPANY (US) 2014-05-15 US disclosed
EP-2730431-A1 Rubber composition and tire with rubber containing flavone The Goodyear Tire & Rubber Company (US) 2014-05-14 EP disclosed
EP-1391327-B1 Tire with rubber containing flavone GOODYEAR TIRE & RUBBER (US) 2008-09-03 EP disclosed
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 US disclosed
EP-1391327-A1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2004-02-25 EP disclosed
WO-2003057210-A1 COMPOSITIONS AND METHODS FOR INCREASING CELL PROLIFERATION COMPRISING A FLAVONOID KIMBERLY-CLARK WORLDWIDE, INC. (US) 2003-07-17 WO disclosed
US-20030125264-A1 Methods For Treating Wounds KIMBERLY-CLARK WORLDWIDE, INC. 2003-07-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030125264-A1 Methods For Treating Wounds FGF2, MMP1, FIBP ABCB1 2498/4885MEN1 3867/4885KMT2A 4306/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.