Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2247941 | 0.88 | MMP2 (0.56) | MMP2ADAMTS4ADAMTS5P2RY12CTSB | |
| SCHEMBL2247356 | 0.83 | MMP2 (0.57) | HPGDTDP1MMP2ADAMTS4ADAMTS5 | |
| SCHEMBL3583743 | 0.79 | ADAMTS5 (0.56) | MMP2ADAMTS4ADAMTS5P2RY12CTSB | |
| SCHEMBL3576509 | 0.78 | ADAMTS5 (0.62) | MMP2ADAMTS4ADAMTS5MAPK1CTSB | |
| SCHEMBL2246985 | 0.77 | ADAMTS5 (0.59) | MMP2ADAMTS4ADAMTS5MEN1KMT2A | |
| SCHEMBL2246335 | 0.77 | MMP2 (0.58) | MMP2ADAMTS4ADAMTS5CTSBCTSL | |
| SCHEMBL3591190 | 0.77 | CTSB (0.55) | MMP2ADAMTS4ADAMTS5CTSBCTSL | |
| SCHEMBL2245471 | 0.77 | MMP2 (0.69) | MMP2ADAMTS4ADAMTS5CTSBCTSL | |
| SCHEMBL2244723 | 0.77 | ADAMTS5 (0.56) | MMP2ADAMTS4ADAMTS5CTSBCTSL | |
| SCHEMBL2247357 | 0.76 | MMP2 (0.61) | MMP2ADAMTS4ADAMTS5CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | disclosed |