SCHEMBL465027

SCHEMBL465027

Clc1cccc2[c]cc[c]c12

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.36
CYP2A6 P11509 2/20 0.36
TSHR P16473 2/20 0.35
LMNA P02545 1/20 0.35
ALDH1A1 P00352 2/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7425157 0.71 CYP1A2 (0.36) CYP1A2CYP2A6TSHRLMNAALDH1A1
SCHEMBL2256297 0.71 CYP1A2 (0.42) CYP1A2CYP2A6TSHRALDH1A1
SCHEMBL457356 0.71 CYP1A2 (0.41) CYP1A2CYP2A6TSHRLMNAALDH1A1
SCHEMBL638983 0.70 CYP1A2 (0.52) CYP1A2CYP2A6TSHRLMNAALDH1A1
SCHEMBL7793838 0.70 CYP1A2 (0.52) CYP1A2CYP2A6TSHRLMNAALDH1A1
SCHEMBL2285983 0.67 CA1 (0.42) TSHRLMNAALDH1A1TDP1
SCHEMBL70280 0.67 CYP2A6 (0.31) CYP1A2CYP2A6
SCHEMBL3896844 0.66 NR4A2 (0.43) CYP1A2CYP2A6LMNAALDH1A1MEN1
SCHEMBL29207353 0.66 CYP1A2 (0.35) CYP1A2CYP2A6
SCHEMBL4467440 0.66 ALDH1A1 (0.35) CYP1A2CYP2A6ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7244789-B2 Fluoroelastomer compositions, their preparation, and their use ILLINOIS TOOL WORKS, INC. (US) 2007-07-17 US claimed
EP-1386943-B1 Fluoroelastomer compositions, their preparation, and their use ILLINOIS TOOL WORKS (US) 2005-09-21 EP claimed
US-6921796-B2 Fluoroelastomer compositions, their preparation, and their use ILLINOIS TOOL WORKS, INC. (US) 2005-07-26 US claimed
US-20050137352-A1 A fluoroelastomer, a bisphenol curative, and a peroxide curative provides non-post cure flurorelastomer material, exhibits an improved compression set resistance ILLINOIS TOOL WORKS, INC. 2005-06-23 US claimed
US-20040024133-A1 Fluoroelastomer compositions, their preparation, and their use ILLINOIS TOOL WORKS, INC., A DELAWARE CORPORATION 2004-02-05 US claimed
EP-1386943-A1 Fluoroelastomer compositions, their preparation, and their use ILLINOIS TOOL WORKS INC. (US) 2004-02-04 EP claimed
EP-3999336-B1 COMPOSITE MATERIAL COMPRISING POLYAMIDE AND FLUOROELASTOMER SOLVAY SPECIALTY POLYMERS IT (IT) 2024-04-03 EP disclosed
EP-3941974-B1 FLUOROELASTOMER COMPOSITION SOLVAY SPECIALTY POLYMERS IT (IT) 2023-11-08 EP disclosed
EP-3999336-A1 COMPOSITE MATERIAL COMPRISING POLYAMIDE AND FLUOROELASTOMER Solvay Specialty Polymers Italy S.p.A. (IT) 2022-05-25 EP disclosed
US-20220135774-A1 FLUOROELASTOMER COMPOSITION SOLVAY SPECIALTY POLYMERS ITALY S.P.A. (IT) 2022-05-05 US disclosed
CN-114126862-A Composite material comprising polyamide and fluoroelastomer 索尔维特殊聚合物意大利有限公司 2022-03-01 CN disclosed
EP-3941974-A1 FLUOROELASTOMER COMPOSITION Solvay Specialty Polymers Italy S.p.A. (IT) 2022-01-26 EP disclosed
EP-3752562-B1 FLUOROELASTOMER CURABLE COMPOSITION SOLVAY SPECIALTY POLYMERS IT (IT) 2022-01-12 EP disclosed
US-4663395-A PHOSPHONIUM PHOSPHONATE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-05-05 US disclosed
EP-0127318-B1 CURABLE FLUOROPOLYMER COMPOSITION E.I. DU PONT DE NEMOURS AND COMPANY (US) 1987-04-01 EP disclosed
EP-0209891-A2 Fluoroelastomer composition containg acceleration E.I. DU PONT DE NEMOURS AND COMPANY (US) 1987-01-28 EP disclosed
EP-0140207-A2 A process for rapidly curing a brominated fluoroelastomer E.I. DU PONT DE NEMOURS AND COMPANY (US) 1985-05-08 EP disclosed
US-4489196-A CONTAINING VULCANIZATION ACCELERATOR, CROSSLINKING AGENT, METAL OXIDE OR HYDROXIDE, AND POLYOL COACCELERATOR E. I. DU PONT DE NEMOURS AND COMPANY (US) 1984-12-18 US disclosed
EP-0127318-A1 Curable fluoropolymer composition E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-12-05 EP disclosed
US-4233421-A AROMATIC POLYHYDROXY CO-CURATIVE IN A THERMALLY STABLE, CORROSION RESISTANT POLYMER MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1980-11-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220135774-A1 FLUOROELASTOMER COMPOSITION FLNA, BET1, FLNB CYP1A2 3294/4885CYP2A6 3616/4885TSHR 4043/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.