SCHEMBL4650466

SCHEMBL4650466

COc1ccc(C2=NNC(=O)OC2c2ccc(OC)cc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.49
GAA P10253 1/20 0.49
PDE3B Q13370 7/20 0.47
PDE3A Q14432 7/20 0.47
PDE4A P27815 2/20 0.42
PDE4B Q07343 2/20 0.42
PDE4C Q08493 2/20 0.42
PDE4D Q08499 2/20 0.42
KMT2A Q03164 2/20 0.40
RAB9A P51151 2/20 0.40
NPC1 O15118 1/20 0.40
MEN1 O00255 1/20 0.40
ALDH1A1 P00352 1/20 0.40
MAPK1 P28482 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
EGFR P00533 1/20 0.40
ABL1 P00519 1/20 0.39
RIN1 Q13671 1/20 0.39
NOTUM Q6P988 1/20 0.39
LMNA P02545 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL212810 0.77 CA2 (0.50) KDM4EGAAPDE3BPDE3APDE4A
SCHEMBL10545135 0.72 CA2 (0.61) KDM4EKMT2ARAB9ANPC1ALDH1A1
SCHEMBL3938706 0.70 KDM4E (0.48) KDM4EGAAPDE3BPDE3APDE4A
SCHEMBL10811816 0.70 PDE3B (0.50) KDM4EGAAPDE3BPDE3APDE4A
SCHEMBL6026843 0.68 ME2 (0.46) KDM4EGAAPDE4DKMT2ARAB9A
SCHEMBL2844785 0.68 PDE3B (0.68) KDM4EPDE3BPDE3APDE4APDE4B
SCHEMBL11365959 0.68 HRH3 (0.59) KDM4EGAAPDE4APDE4BPDE4C
SCHEMBL3939017 0.66 PDE3B (0.50) KDM4EGAAPDE3BPDE3APDE4A
SCHEMBL1373505 0.66 PDE3B (0.50) KDM4EGAAPDE3BPDE3APDE4A
SCHEMBL11964001 0.66 KDM4E (0.49) KDM4EGAAKMT2ARAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1963432-A1 EXPANDED AND EXPANDABLE HIGH GLASS TRANSITION TEMPERATURE POLYMERS General Electric Company (US) 2008-09-03 EP disclosed
WO-2007078737-A1 EXPANDED AND EXPANDABLE HIGH GLASS TRANSITION TEMPERATURE POLYMERS GENERAL ELECTRIC COMPANY (US) 2007-07-12 WO disclosed
US-20070149629-A1 Expanded and expandable high glass transition temperature polymers CITIBANK, N.A., AS COLLATERAL AGENT 2007-06-28 US disclosed
EP-0181000-A2 Foamable polyetherimide resin formulation GENERAL ELECTRIC COMPANY (US) 1986-05-14 EP disclosed
US-4543368-A DIHYDRODIAZINONE BLOWING AGENT GENERAL ELECTRIC COMPANY (US) 1985-09-24 US disclosed
US-4334030-A INJECTION MOLDABLE CONCENTRATES CONTAINING AMIDE DERIVATIVES OF AZODICARBOXYLIC ACID AND A DIHYDROOXADIAZINONE AS BLOWING AGENTS GENERAL ELECTRIC COMPANY (US) 1982-06-08 US disclosed
US-4163037-A USING A DIHYDROOXADIAZINONE BLOWING AGENT, INJECTION MOLDING GENERAL ELECTRIC COMPANY (US) 1979-07-31 US disclosed
US-4160088-A HALOGENATION OF KETONE, ALKANOL, HYDROLYSIS GENERAL ELECTRIC COMPANY (US) 1979-07-03 US disclosed
US-4158094-A BLOWING AGENTS GENERAL ELECTRIC COMPANY (US) 1979-06-12 US disclosed
US-4097671-A 5-PHENYL-3,6-DIHYDRO-1,3,4-OXADIAZIN-2-ONE, THERMOPLASTIC POLYMER BLOWING AGENT GENERAL ELECTRIC COMPANY (US) 1978-06-27 US disclosed
US-4097425-A POLYCARBONATES, POLYESTERS, SUBSTITUTED 3,6-DIHYDRO-1,3,4-OXDIAZIN-2-ONE GENERAL ELECTRIC COMPANY (US) 1978-06-27 US disclosed