SCHEMBL4650535

SCHEMBL4650535

C=CCC1=Cc2c(cccc2CC=C)[CH]1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 2/20 0.42
GABRB2 P47870 2/20 0.42
AKR1B1 P15121 1/20 0.33
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
MAPT P10636 1/20 0.32
MAPK1 P28482 1/20 0.32
ALDH1A1 P00352 2/20 0.31
KDM4E B2RXH2 1/20 0.31
AURKA O14965 1/20 0.31
DAPK3 O43293 1/20 0.31
MAP4K4 O95819 1/20 0.31
RET P07949 1/20 0.31
IGF1R P08069 1/20 0.31
MET P08581 1/20 0.31
PIM1 P11309 1/20 0.31
LTK P29376 1/20 0.31
KDR P35968 1/20 0.31
MAPK8 P45983 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6525334 0.82 LIPG (0.39) GABRA1GABRB2MAPTKDM4E
SCHEMBL2956508 0.79 GABRA1 (0.31) GABRA1GABRB2
SCHEMBL4651620 0.77 GABRA1 (0.30) GABRA1GABRB2
SCHEMBL7040493 0.75 MAPT (0.33) GABRA1GABRB2MEN1KMT2AMAPT
SCHEMBL4653119 0.73 GABRA1 (0.34) GABRA1GABRB2
SCHEMBL9092024 0.73 GABRA1 (0.47) GABRA1GABRB2AKR1B1MEN1KMT2A
SCHEMBL4670729 0.71 GABRA1 (0.50) GABRA1GABRB2AKR1B1MEN1KMT2A
SCHEMBL3275837 0.69 GABRA1 (0.43) GABRA1GABRB2AKR1B1MEN1KMT2A
SCHEMBL2885407 0.68 GABRA1 (0.39) GABRA1GABRB2AKR1B1MEN1KMT2A
SCHEMBL5824091 0.67 GABRA1 (0.58) GABRA1GABRB2AKR1B1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1188763-B1 Metallocenes and their use in olefin polymerisation BASELL POLYOLEFINE GMBH (DE) 2005-03-09 EP claimed
EP-1188763-A2 Metallocenes and their use in olefin polymerisation Basell Polyolefine GmbH (DE) 2002-03-20 EP claimed
US-5693730-A METALLOCENES HAVING MORE THAN ONE CENTRAL ATOM AND A SPECIAL BRIDGE STRUCTURE FOR PREPARING ISOTACTIC, HIGH-MOLECULAR-WEIGHT POLYMERS HAVING GOOD GRAIN MORPHOLOGY; PROPYLENE HOMO- AND COPOLYMERS HOECHST AKTIENGESELLSCHAFT (DE) 1997-12-02 US claimed
EP-0906932-B1 Film and stretch packaging film DENKI KAGAKU KOGYO KK (JP) 2008-07-02 EP disclosed
EP-1188763-B1 Metallocenes and their use in olefin polymerisation BASELL POLYOLEFINE GMBH (DE) 2005-03-09 EP disclosed
US-6472490-B1 AN ETHYLENE-AROMATIC VINYL COMPOUND COPOLYMER HAVING AN AROMATIC VINYL COMPOUND CONTENT OF FROM 1 TO LESS THAN 55% BY MOLAR FRACTION, WHICH HAS A HAZE OF AT MOST 41.5% WHEN MOLDED; METHINE DYES DENKI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2002-10-29 US disclosed
US-6417308-B2 A HOMO- OR COPOLYMER OF AN ALPHA-OLEFIN WITH AN AROMATIC VINYL COMPOUND OF AN ALTERNATING, HIGHLY ISOTACTIC STRUCTURE WITH HEAD-TO TAIL CHAINS OF AT LEAST TWO AROMATIC VINYLS; FOOD PACKAGING; SELF-ADHESIVE; STRENGTH DENKI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2002-07-09 US disclosed
EP-0659756-B1 Metallocenes BASELL POLYOLEFINE GMBH (DE) 2002-04-03 EP disclosed
EP-0659757-B1 Metallocenes BASELL POLYOLEFINE GMBH (DE) 2002-03-27 EP disclosed
EP-1188763-A2 Metallocenes and their use in olefin polymerisation Basell Polyolefine GmbH (DE) 2002-03-20 EP disclosed
US-6348556-B1 COORDINATION CATALYST OF TRANSITION METAL COMPLEX CONTAINING INDENYL GROUP(S) AND COCATALYST; ISOTACTIC; CATALYSIS, ADDITION COPOLYMERIZATION DENKI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2002-02-19 US disclosed
US-5693730-A METALLOCENES HAVING MORE THAN ONE CENTRAL ATOM AND A SPECIAL BRIDGE STRUCTURE FOR PREPARING ISOTACTIC, HIGH-MOLECULAR-WEIGHT POLYMERS HAVING GOOD GRAIN MORPHOLOGY; PROPYLENE HOMO- AND COPOLYMERS HOECHST AKTIENGESELLSCHAFT (DE) 1997-12-02 US disclosed
US-5612428-A CATALYTIC POLYMERIZATION WITH COORDINATION COMPLEXES WITH GROUP IVB METALS AND COCATALYSTS HOECHST AKTIENGESELLSCHAFT (DE) 1997-03-18 US disclosed
US-5585508-A POLYMERIZATION CATALYST FOR POLYOLEFINS HOECHST AG (DE) 1996-12-17 US disclosed
US-5576260-A POLYMERIZATION CATALYSTS FOR OLEFINS HOECHST AKTIENGESELLSCHAFT (DE) 1996-11-19 US disclosed
US-5543373-A OLEFIN POLYMERIZATION CATALYST HOECHST AG (DE) 1996-08-06 US disclosed
US-5532396-A HAS TWO INDENYL LIGANDS WITH DIFFERENT SUBSTITUTION PATTERNS ON THE SIX-MEMBERED RINGS. LIGANDS ARE JOINED BY DIVALENT GROUP CONNECTING FIVE-MEMBERED RINGS. METAL IS FROM GROUP /IVB/, /VB/ OR /VIB/. OLEFIN POLYMERIZATION CATALYST HOECHST AKTIENGESELLSCHAFT (DE) 1996-07-02 US disclosed
EP-0659756-A1 Metallocenes HOECHST AKTIENGESELLSCHAFT (DE) 1995-06-28 EP disclosed
EP-0659757-A1 Metallocenes HOECHST AKTIENGESELLSCHAFT (DE) 1995-06-28 EP disclosed
EP-0654476-A1 Metallocenes, their preparation and use as catalysts HOECHST AKTIENGESELLSCHAFT (DE) 1995-05-24 EP disclosed