SCHEMBL465059

SCHEMBL465059

CCCCOS(=O)(=O)N1CCOCC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 6/20 0.46
LMNA P02545 3/20 0.46
POLB P06746 1/20 0.46
CA1 P00915 7/20 0.42
CA2 P00918 7/20 0.42
CA12 O43570 2/20 0.42
CA7 P43166 2/20 0.42
CA14 Q9ULX7 2/20 0.42
ALDH1A1 P00352 3/20 0.41
MAPK1 P28482 2/20 0.41
CYP1A2 P05177 1/20 0.41
CHRM2 P08172 1/20 0.41
CHRM1 P11229 1/20 0.41
HTR2A P28223 1/20 0.41
SCN1A P35498 1/20 0.41
HTR2B P41595 1/20 0.41
KCNH2 Q12809 1/20 0.41
SCN2A Q99250 1/20 0.41
SIGMAR1 Q99720 1/20 0.41
SCN3A Q9NY46 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL709157 0.89 CA12 (0.45) SMN1; SMN2LMNAPOLBCA1CA2
SCHEMBL27263918 0.87 CA12 (0.43) SMN1; SMN2LMNAPOLBCA1CA2
Water SCHEMBL27737003 0.86 CA12 (0.42) SMN1; SMN2LMNAPOLBCA1CA2
SCHEMBL465093 0.81 CA12 (0.48) SMN1; SMN2LMNACA12CA7CA14
Water SCHEMBL27714980 0.79 CA12 (0.46) SMN1; SMN2LMNACA12CA7CA14
SCHEMBL27896468 0.79 CA12 (0.46) SMN1; SMN2LMNACA12CA7CA14
SCHEMBL17443158 0.74 CA1 (0.46) SMN1; SMN2CA1CA2CA12CA7
SCHEMBL7297373 0.72 ALDH1A1 (0.50) SMN1; SMN2LMNAPOLBCA12CA7
SCHEMBL21210697 0.70 LMNA (0.49) SMN1; SMN2LMNAPOLBCA12CA7
SCHEMBL13968028 0.70 CA12 (0.54) SMN1; SMN2LMNAPOLBCA12CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112105367-A Buffered microcapsule compositions and methods 第一牙科产品公司 2020-12-18 CN claimed
CN-102380100-A Stable protease composition TROBIO AB 2012-03-21 CN claimed
EP-1637141-B1 Stabilized protease composition comprising a serine protease, morpholino derivatives and reversible inhibitors of said serine protease TROBIO AB (SE) 2011-11-16 EP claimed
WO-2011131234-A1 SENSOR APPARATUS ADAPTED TO BE INCORPORATED IN A GARMENT WEARABLE INFORMATION TECHNOLOGIES, S.L. (WEARTECH) (ES) 2011-10-27 WO claimed
US-20090136474-A1 Stabilized Protease Composition TROBIO AB (SE) 2009-05-28 US claimed
CN-101272790-A Stable protease compositions TROBIO AB (SE) 2008-09-24 CN claimed
WO-2007035143-A1 STABILIZED PROTEASE COMPOSITION TROBIO AB (SE) 2007-03-29 WO claimed
EP-1637141-A1 Stabilized protease composition comprising a serine protease, morpholino derivatives and reversible inhibitors of said serine protease Trobio AB (SE) 2006-03-22 EP claimed
CN-112105367-A Buffered microcapsule compositions and methods 第一牙科产品公司 2020-12-18 CN disclosed
US-8574569-B2 Stabilized protease composition TROBIO AB (SE) 2013-11-05 US disclosed
CN-101677947-B Pharmaceutical formulation comprising an insulin derivative NOVO NORDISK AS 2013-07-17 CN disclosed
US-20130157339-A1 STABILIZED PROTEASE COMPOSITION TROBIO AB (SE) 2013-06-20 US disclosed
US-8394372-B2 Stabilized protease composition TROBIO AB (SE) 2013-03-12 US disclosed
CN-102666584-A Blocking anti-DKK-1 antibodies and their uses PFIZER 2012-09-12 CN disclosed
CN-101705186-A Defined cell culture surfaces and methods of use thereof BECTON DICKINSON CO 2010-05-12 CN disclosed
CN-101677947-A pharmaceutical formulation comprising an insulin derivative NOVO NORDISK AS 2010-03-24 CN disclosed
US-20090136474-A1 Stabilized Protease Composition TROBIO AB (SE) 2009-05-28 US disclosed
CN-101272790-A Stable protease compositions TROBIO AB (SE) 2008-09-24 CN disclosed
WO-2007035143-A1 STABILIZED PROTEASE COMPOSITION TROBIO AB (SE) 2007-03-29 WO disclosed
EP-1637141-A1 Stabilized protease composition comprising a serine protease, morpholino derivatives and reversible inhibitors of said serine protease Trobio AB (SE) 2006-03-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090136474-A1 Stabilized Protease Composition SERPINE1, SERPINB1, CTRL SMN1; SMN2 655/4885LMNA 505/4885POLB 3135/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.