Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.57 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.52 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.52 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.52 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3176740 | 0.84 | HIF1A (0.56) | HIF1ACNR1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL1180411 | 0.80 | HIF1A (0.67) | HIF1ACNR1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL5598218 | 0.76 | HIF1A (0.85) | HIF1ACNR1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL27680999 | 0.76 | HIF1A (0.60) | HIF1ACNR1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL1010214 | 0.76 | MTNR1A (0.61) | HIF1ACNR1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL5602996 | 0.75 | ALDH1A1 (0.69) | HIF1ACNR1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL7220257 | 0.74 | EGFR (0.54) | HPGDLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL17442696 | 0.73 | HIF1A (0.57) | HIF1ACNR1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL14241832 | 0.73 | HIF1A (0.57) | HIF1ACNR1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL9425562 | 0.73 | HIF1A (0.57) | HIF1ACNR1PLAAT3PLAAT5PLAAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966141-A1 | SIX-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007070818-A1 | SIX-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-21 | — | — | WO | disclosed |